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上海药物研究所 [5]
湖南中医药大学 [3]
中国医学科学院 北京... [2]
厦门大学 [1]
武汉物理与数学研究所 [1]
上海中医药大学 [1]
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期刊论文 [12]
学位论文 [1]
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Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment
期刊论文
NANO LETTERS, 2021, 卷号: 21, 期号: 7, 页码: 3033-3043
作者:
He, Wenxiu
;
Mei, Qiyong
;
Li, Jie
;
Zhai, Yuting
;
Chen, Yiting
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/06/11
ischemic stroke
blood-brain barrier
bioinspired nanovehicle
cell membrane
drug delivery
Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway
期刊论文
2019, 卷号: 40, 期号: 1, 页码: 13-25
作者:
Chu, Shi-feng
;
Zhang, Zhao
;
Zhou, Xin
;
He, Wen-bin
;
Chen, Chen
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
stroke
ginsenoside
Rg1
ischemic/reperfusion
oxidative stress
Nrf2/ARE
miR-144
PC12 cells
tMCAO rats
IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation
期刊论文
2019, 卷号: 212, 页码: 36-53
作者:
Ai Q D
;
Chen Chen
;
Chu Shifeng
;
Zhang Zhao
;
Luo Yun
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/01/03
ASC = apoptosis-associated speck-like protein containing a caspase activation recruitment domain
BCA = bicinchoninic acid
BSA = bovine serum albumin
CCA = common carotid artery
CCR4 = C-C chemokine receptor type 4
CKLF1 = chemokine-like factor 1
CO-IP = coimmunoprecipitation
ECA = external carotid artery
ELISA = enzyme-linked immunosorbent assay
FDA = Food and Drug Administration
I/R = ischemic/reperfusion
ICA = internal carotid artery
IL-18 = interleukin 18
IL-1β = interleukin 1β
LDH = lactate dehydrogenase
NLRP3 = NOD-like receptor protein 3
PBS = phosphate-buffered saline
SD = standard deviation
TNF-α = tumor necrosis factor α
TTC = 2
3
5-triphenyltetrazolium-chloride
WT = wild-type
pMCAO = permanent middle cerebral artery occlusion
pro-Caspase-1 = precursor Caspase-1
qPCR = quantitative real-time PCR
tMCAO = transient middle cerebral artery occlusion
tPA = tissue plasminogen activator
Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway
期刊论文
Acta Pharmacologica Sinica, 2019, 卷号: 40, 期号: 1, 页码: 13-25
作者:
Chu, Shi-feng
;
Zhang, Zhao
;
Zhou, Xin
;
He, Wen-bin
;
Chen, Chen
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/27
Nrf2/ARE
PC12 cells
Rg1
ginsenoside
ischemic/reperfusion
miR-144
oxidative stress
stroke
tMCAO rats
NK cells in cerebral ischemia
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, 卷号: 109, 页码: 547-554
作者:
Chen, Chen
;
Ai, Qi-Di
;
Chu, Shi-Feng
;
Zhang, Zhao
;
Chen, Nai-Hong*
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/12/27
tPA
tissue plasminogen activator
IS
ischemic stroke
BBB
blood-brain barrier
IFN-γ
interferon-γ
pMCAO
permanent middle cerebral artery occlusion
tMCAO
transient middle cerebral artery occlusion
CX3CR1
CX3CL1 receptor
CNS
central nervous system
AchE
acetylcholine esterase
CFSE
arboxyfluorescein diacetate succinimidyl ester
HI
hypoxic ischemia
MCAO IP-10
interferon-inducible protein-10
IL
interleukin
GFAP
glial fibrillary acidic protein
tg
transgenic
WT
wild-type
APC
antigen presenting cell
SAI
stroke-associated infection
STAT3
signal transducer and activator of transcription-3
HPA
hypothalamic-pituitary-adrenal
cSVD
cerebral small vessel disease
SHR
spontaneously hypertensive rat
CSF
cerebrospinal fluid
aSAH
aneurysmal subarachnoid hemorrhage
DCI
delayed cerebral ischemia
MRI
magnetic resonance imaging
CT
computed tomography
EVs
extracellular vesicles
MSC
mesenchymal stem cell
MNCs
bone marrow-derived mononuclear cells
CpG-ODN
cytosine-guanine oligodideoxynucleotide
TLR9
toll-like receptor 9
TNF
tumor necrosis factor
NK cells
Cerebral ischemia
Inflammation
Immunodpression
Infection
The PGC-1 alpha Activator ZLN005 Ameliorates Ischemia-Induced Neuronal Injury In Vitro and In Vivo
期刊论文
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2018, 卷号: 38, 期号: 4, 页码: 929-939
作者:
Xu, Yazhou
;
Kabba, John Alimamy
;
Ruan, Wenchen
;
Wang, Yunjie
;
Zhao, Shunyi
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
Ischemic stroke
PGC-1 alpha
HO-1
Neuroprotection
Chemokines play complex roles in cerebral ischemia
期刊论文
Neurochemistry International, 2018, 卷号: 112, 页码: 146-158
作者:
Chen, Chen
;
Chu, Shi-Feng
;
Liu, Dan-Dan
;
Zhang, Zhao
;
Kong, Ling-Lei
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/12/27
Chemokine
Cerebral ischemia
Ischemic stroke
IS
ischemic stroke
NSCs
neural stem cell
NPCs
neural progenitor cells
BMSCs
bone marrow stromal cells
ELR
glutamic acid-leucine-arginine
MCP
monocytes chemoattractant protein
MCAo
middle cerebral artery occlusion
tMCAo
transient MCAo
CNS
central nervous system
MIP
macrophage inflammatory protein
BBB
blood brain barrier
HI
hypoxia ischemia
CSF
cerebrospinal fluid
CI
cerebral infarction
WT
wildtype
pMCAo
permanent MCAo
ET
endothelin
I/R
ischemia/reperfusion
SCID
Severe Combined Immunodeficiency
ENA-78
epithelial neutrophil-activating peptide-78
IL-8
interleukin 8
PMNL
polymorphonuclear leukocyte
MSCs
mesenchymal stem cells
VEGF
vascular endothelial growth factor
CINC
cytokine-induced neutrophil chemoattractant
IP-10
interferon-gamma inducible protein-10
NK
natural killer
SDF-1
stromal cell-derived factor-1
EPCs
endothelial progenitor cells
HSCs
hematopoietic stem cells
HUVECs
human umbilical vein endothelial cells
TIA
transient ischemic attack
OGD
oxygen glucose deprivation
GPCs
glial precursor cells
CMKLR1
chemerin-like receptor-1
AIS
acute ischemic stroke
CKLF1
chemokine-like factor 1
CBP
chemokine-binding protein
A novel GSK-3 beta inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 6, 页码: 741-752
作者:
Pang, Tao
;
Wang, Yun-jie
;
Gao, Yuan-xue
;
Xu, Yuan
;
Li, Qiu
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
GSK-3 beta inhibitor
YQ138
cerebellar granule cells
glutamate excitotoxicity
OGD
middle cerebral artery occlusion
brain ischemia
neuroprotection
Nrf2
NAD~+对tMCAO小鼠的脑保护作用
期刊论文
卒中与神经疾病, 2016, 卷号: 23, 期号: 05
作者:
陈昕
;
魏珍玉
;
岳丹丹
;
潘杰
;
钟萍
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
缺血再灌注损伤
NAD~+
保护
A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway
期刊论文
中国药理学报:英文版, 2016, 卷号: 000, 期号: 006, 页码: 741
作者:
Pang Tao
;
Wang Yunjie
;
Gao Yuanxue
;
Xu Yuan
;
Li Qiu
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/24
神经元损伤
酶抑制剂
谷氨酸
脑缺血
诱导
信号通路
神经保护作用
β-catenin
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