Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment

doi:10.1021/acs.nanolett.1c00231

	Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment
	He, Wenxiu 1; Mei, Qiyong 2; Li, Jie 3,4; Zhai, Yuting 5; Chen, Yiting 1; Wang, Rui 1; Lu, Enhao 1; Zhang, Xiao-Yong 5,6; Zhang, Zhiwen 3,4; Sha, Xianyi 1,7
刊名	NANO LETTERS
	2021-04-14
卷号	21 期号:7 页码:3033-3043
关键词	ischemic stroke blood-brain barrier bioinspired nanovehicle cell membrane drug delivery
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.1c00231
通讯作者	Zhang, Xiao-Yong(xiaoyong_zhang@fudan.edu.cn) ; Zhang, Zhiwen(zwzhang0125@simm.ac.cn) ; Sha, Xianyi(shaxy@fudan.edu.cn)
英文摘要	The poor drug delivery to cerebral ischemic regions is a key challenge of ischemic stroke treatment. Inspired by the intriguing blood-brain barrier (BBB)-penetrating ability of 4T1 cancer cells upon their brain metastasis, we herein designed a promising biomimetic nanoplatform by camouflaging a succinobucol-loaded pH-sensitive polymeric nanovehicle with a 4T1 cell membrane (MPP/SCB), aiming to promote the preferential targeting of cerebral ischemic lesions to attenuate the ischemia/reperfusion injury. In transient middle cerebral artery occlusion (tMCAO) rat models, MPP/SCB could be preferentially delivered to the ischemic hemisphere with a 4.79-fold higher than that in the normal hemisphere. Moreover, MPP/SCB produced notable enhancement of microvascular reperfusion in the ischemic hemisphere, resulting in a 69.9% reduction of infarct volume and showing remarkable neuroprotective effects of tMCAO rats, which was superior to the counterpart uncamouflaged nanovehicles (PP/SCB). Therefore, this design provides a promising nanoplatform to target the cerebral ischemic lesions for ischemic stroke therapy.
资助项目	National Natural Science Foundation of China[81773201] ; National Natural Science Foundation of China[81873893] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005] ; PDH-SPFDU Joint Research Fund[RHJJ2018-02] ; Development Project of Shanghai Peak Disciplines-Integrative Medicine[20180101] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX01] ; ZJLab
WOS关键词	BREAST-CANCER ; NANOPARTICLES ; EXPRESSION ; DELIVERY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000641160500045
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296564]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Xiao-Yong; Zhang, Zhiwen; Sha, Xianyi
作者单位	1.Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China 2.Naval Med Univ, Changzheng Hosp, Dept Neurosurg, Shanghai 200003, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai 200433, Peoples R China 6.Minist Educ, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai 200433, Peoples R China 7.Fudan Univ, Inst Integrat Med, Shanghai 200040, Peoples R China
推荐引用方式 GB/T 7714	He, Wenxiu,Mei, Qiyong,Li, Jie,et al. Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment[J]. NANO LETTERS,2021,21(7):3033-3043.
APA	He, Wenxiu.,Mei, Qiyong.,Li, Jie.,Zhai, Yuting.,Chen, Yiting.,...&Sha, Xianyi.(2021).Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment.NANO LETTERS,21(7),3033-3043.
MLA	He, Wenxiu,et al."Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment".NANO LETTERS 21.7(2021):3033-3043.