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Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors
期刊论文
PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 卷号: 55, 期号: 7, 页码: 655-664
作者:
Xu, Jianghong
;
Hu, Yuanyuan
;
Liu, Xiaoqi
;
Gao, Anhui
;
Gao, Lixin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/12/01
IDH1-R132H inhibitors
synthesis
biological activity
docking
3-(indol-3-yl)-4-(pyrazolo-[3
4-c]pyridazin-3-yl)-maleimides
Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2021, 页码: 8
作者:
Hu, Shulei
;
Han, Xu
;
Xie, Xiong
;
Fang, Feifei
;
Wang, Yong
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/08/17
annulation reactions
C-H activation
pyrazolidinone
Rhodium (III)-catalyzed
sulfoxonium ylide
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
Pd-Catalyzed intramolecular C-H activation and C-S formation to synthesize pyrazolo[5,1-b]benzothiazoles without an additional oxidant
期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 18, 页码: 3234-3237
作者:
Peng, Yingyuan
;
He, Qian
;
Zhang, Xiaofei
;
Yang, Chunhao
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  |  
浏览/下载:1/0
  |  
提交时间:2020/07/01
Synthesis and biological evaluation of novel 1-substituted 3-(3-phenoxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 2
作者:
Zheng, Nan
;
Hao, Qun
;
Lin, Kuaile
;
Pan, Jing
;
Li, Yingxia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
BTK inhibitors
1-Substituted pyrazolo[3,4-d]pyrimidine
Inhibitory activity
B-cell lymphoblastic leukemia
Cytotoxicity
Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis
期刊论文
ACS Infectious Diseases, 2019, 卷号: Vol.5 No.2, 页码: 239-249
作者:
Kiel Hards
;
Chen-Yi Cheung
;
Xiantao Zhang
;
Gregory M. Cook
;
Kyu Rhee
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/04/24
cytochrome
bcc
complex
Mycobacterium
tuberculosis
QcrB
respiratory
inhibitor
tuberculosis
Iridium-Catalyzed Tandem Annulation Synthesis of Pyrazolo[1,2-α]cinnolines from Pyrazolones and Sulfoxonium Ylides
期刊论文
The Journal of Organic Chemistry, 2019, 卷号: Vol.84 No.1, 页码: 409-416
作者:
Chen-Fei Liu
;
Man Liu
;
Lin Dong
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/02/25
3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.168, 页码: 426-435
作者:
Min'an Zhai
;
Shiyuan Liu
;
Meiqi Gao
;
Long Wang
;
Jun Sun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/13
Ring tethering
Conformational analysis
Pyrazolo[3,4-b]pyridine
Colchicine site
Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold
期刊论文
2019, 卷号: 27, 期号: 8, 页码: 1562-1576
作者:
Yin, Yuan
;
Chen, Cheng-Juan
;
Yu, Ru-Nan
;
Shu, Lei
;
Zhang, Tian-Tai
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/03
JAK2
Inhibitor
1H-pyrazolo[3
4-d]pyrimidin-4-amino
Intramolecular hydrogen bond
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