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23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 327-335
作者:
Li, Hui-hui
;
Li, Jun
;
Zhang, Xian-jing
;
Li, Jiao-meng
;
Xi, Cong
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
23,24-dihydrocucurbitacin B
lipid-lowering agent
LDLR
PCSK9
HNF1 alpha
SREBP2
2324dihydrocucurbitacinbpromoteslipidclearancebydualtranscriptionalregulationofldlrandpcsk9
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 327
作者:
Li Huihui
;
Li Jun
;
Zhang Xianjing
;
Li Jiaomeng
;
Xi Cong
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
23
24-dihydrocucurbitacin B
lipid-lowering agent
LDLR
PCSK9
HNF1α
SREBP2
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
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  |  
浏览/下载:48/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Effect of Quercetin on Atherosclerosis Based on Expressions of ABCA1, LXR-α and PCSK9 in ApoE-/- Mice.
期刊论文
Chinese journal of integrative medicine, 2019
作者:
Jia Qing-Ling
;
Dou Fang-Fang
;
Xing San-Li
;
Chen Chuan
;
Shen Ding-Zhu
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  |  
浏览/下载:68/0
  |  
提交时间:2019/12/05
ATP binding cassette transporter A1
atherosclerosis
liver X receptor
proprotein convertase subtilisin/kexin type 9
quercetin
Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPAR gamma, LXR alpha and ABCA1
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2019, 卷号: 44, 期号: 3
作者:
Jia, Qingling
;
Xing, Sanli
;
Dou, Fangfang
;
Cao, Hui
;
Shen, Dingzhu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/05
quercetin
atherosclerosis
proprotein convertase subtilisin
kexin type 9
cluster of differentiation 36
peroxisome proliferator-activated receptor gamma
liver X receptor alpha
ATP binding cassette transporter A1
PCSK9 Inhibitors: Novel Therapeutic Strategies for Lowering LDL-Cholesterol
期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2019, 卷号: 19, 期号: 2, 页码: 165-176
作者:
Wang, Yan
;
Liu, Zhao-Peng
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  |  
浏览/下载:22/0
  |  
提交时间:2019/12/11
Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9)
low-density lipoprotein cholesterol (LDL-C)
low-density lipoprotein
receptor (LDLR)
cardiovascular disease (CVD)
hypercholesterolemia
alirocmab
evolocumab
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/AktSREBP2 signaling pathway to influence lipid metabolism in HepG2 cells.
期刊论文
International journal of molecular medicine, 2019, 卷号: 43, 期号: 5, 页码: 2055-2063
作者:
Xiao, Jun
;
Bai, Xue-Qin
;
Liao, Ling
;
Zhou, Min
;
Peng, Juan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/27
HepG2 cells
Hydrogen sulfide
Lipid metabolism
Low-density lipoprotein receptor
Phosphoinositide 3-kinase/protein kinase B
Proprotein convertase subtilisin/kexin type 9
Sterol regulatory element-binding protein 2
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/AktSREBP2 signaling pathway to influence lipid metabolism in HepG2 cells.
期刊论文
International journal of molecular medicine, 2019, 卷号: 43, 期号: 5, 页码: 2055-2063
作者:
Xiao, Jun
;
Bai, Xue-Qin
;
Liao, Ling
;
Zhou, Min
;
Peng, Juan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/27
HepG2 cells
Hydrogen sulfide
Lipid metabolism
Low-density lipoprotein receptor
Phosphoinositide 3-kinase/protein kinase B
Proprotein convertase subtilisin/kexin type 9
Sterol regulatory element-binding protein 2
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia
期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:
Wu Chenglin
;
Xi Cong
;
Tong Junhua
;
Zhao Jing
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
DOPAMINE D-1
BERBERINE
EXPRESSION
INHIBITORS
IDENTIFICATION
CHOLESTEROL
MUTATIONS
LDLR
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Indole alkaloid from Nauclea latifolia promotes LDL uptake in HepG2 cells by inhibiting PCSK9
期刊论文
Phytomedicine, 2018
作者:
Aggrey, Mike Okweesi
;
Li, Hui-Hui
;
Wang, Wen-Qiong
;
Wang, Yiping
;
Xuan, Li-Jiang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/03/13
Anti-hyperlipidemia
Nauclea Latifolia
Pcsk9
Sar
Indoloquinolizidine Alkaloids
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