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上海药物研究所 [5]
中国医学科学院 北京... [5]
复旦大学上海医学院 [4]
北京大学 [2]
上海中医药大学 [2]
大连化学物理研究所 [1]
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期刊论文 [20]
会议论文 [1]
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2019 [1]
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物理化学 [1]
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Prediction of Ticagrelor and its Active Metabolite in Liver Cirrhosis Populations Using a Physiologically Based Pharmacokinetic Model Involving Pharmacodynamics
期刊论文
JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 108, 期号: 8
作者:
Zhang, Min
;
You, Xiang
;
Ke, Meng
;
Jiao, Zheng
;
Wu, Hongwei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/05
ticagrelor
active metabolite
physiologically based pharmacokineticmodel
liver cirrhosis populations
inhibition of platelet aggregation
Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2018, 卷号: 175, 期号: 17, 页码: 3486-3503
作者:
Dong, Jiajia
;
Olaleye, Olajide E.
;
Jiang, Rongrong
;
Li, Jing
;
Lu, Chuang
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  |  
浏览/下载:100/0
  |  
提交时间:2019/01/08
Prediction of Drug-Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically-Based Pharmacokinetic Model
期刊论文
PHARMACEUTICS, 2018, 卷号: 10, 期号: 1
作者:
Xue, Caifu
;
Zhang, Xunjie
;
Cai, Weimin
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
physiologically based pharmacokinetic model
drug-drug interactions
bupropion
hydroxybupropion
threohydrobupropion
erythrohydrobupropion
inhibitory metabolites
Novel in vitro dynamic metabolic system for predicting the human pharmacokinetics of tolbutamide
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 9
作者:
Cai-fu Xue
;
Zhe Zhang
;
Yan Jin
;
Bin Zhu
;
Jun-fen Xing
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
physiologically based pharmacokinetic model
FAB hydrogel
microdialysis
tolbutamide
Bio-PK metabolic system
dynamic
human liver microsomes
Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration-Mean Residence Time Methods: M
期刊论文
2018, 卷号: 57, 期号: 10, 页码: 1307-1323
作者:
Song, Ling
;
Zhang, Yi
;
Jiang, Ji
;
Ren, Shuang
;
Chen, Li
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
Comment on: "A Physiologically Based Pharmacokinetic Drug-Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood"
期刊论文
CLINICAL PHARMACOKINETICS, 2016, 卷号: 55, 期号: 1
作者:
Li, Guo-Fu
;
Gu, Xiao
;
Yu, Guo
;
Zhao, Shui-Yu
;
Zheng, Qing-Shan
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Uncertainty analysis in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cancer dose-response for three occupational cohorts
期刊论文
ENVIRONMENT INTERNATIONAL, 2016
Dong, Zhaomin
;
Yuan, Guanxiang
;
Hu, Jianying
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  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
Kinetic model
Dose-response model
Cancer
Effective dose
Dioxin
RISK-ASSESSMENT
PHARMACOKINETIC MODEL
ELIMINATION KINETICS
NIOSH COHORT
BODY-FAT
DIOXIN
EXPOSURE
MORTALITY
AGE
DIBENZOFURANS
Comment on: "A Physiologically Based Pharmacokinetic Drug-Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood"
期刊论文
Clinical pharmacokinetics, 2016, 卷号: 55, 页码: 133-7
作者:
Li Guo-Fu[1]
;
Gu Xiao[2]
;
Yu Guo[3]
;
Zhao Shui-Yu[4]
;
Zheng Qing-Shan[5]
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/04/26
Evaluating a physiologically based pharmacokinetic model for predicting the pharmacokinetics of midazolam in Chinese after oral administration
期刊论文
2016, 卷号: 37, 期号: 2, 页码: 276-84
作者:
Wang Hong-yun
;
Chen Xia
;
Jiang Ji
;
Shi Jun
;
Hu Pei
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/04
Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6
期刊论文
2016, 卷号: 92, 页码: 131-6
作者:
Chen Rui
;
Rostami-Hodjegan Amin
;
Wang Haotian
;
Berk David
;
Shi Jun
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/04
CYP2D6
Phenotyping method
Physiologically based pharmacokinetic model
Virtual population
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