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Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors
期刊论文
PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 卷号: 55, 期号: 7, 页码: 655-664
作者:
Xu, Jianghong
;
Hu, Yuanyuan
;
Liu, Xiaoqi
;
Gao, Anhui
;
Gao, Lixin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/12/01
IDH1-R132H inhibitors
synthesis
biological activity
docking
3-(indol-3-yl)-4-(pyrazolo-[3
4-c]pyridazin-3-yl)-maleimides
Isocitrate Dehydrogenase 2 Inhibitors for the Treatment of Hematologic Malignancies: Advances and Future Opportunities
期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021, 卷号: 21
作者:
Huang, Feng
;
Tian, Tian
;
Wu, Yizhe
;
Che, Jinxin
;
Yang, Haiyan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/06/15
Isocitrate dehydrogenase 2
IDH2
mutant
inhibitors
structure-activity relationship
blood cance
An Integrated Regulatory Network Based on Comprehensive Analysis of mRNA Expression, Gene Methylation and Expression of Long Non-coding RNAs (lncRNAs) in Myelodysplastic Syndromes
期刊论文
FRONTIERS IN ONCOLOGY, 2019, 卷号: 9
作者:
Zhao, Xiaoli
;
Yin, Hua
;
Li, Nianyi
;
Zhu, Yu
;
Shen, Wenyi
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/12/05
myelodysplastic syndromes
differentially expressed genes
methylated genes
microRNAs
lncRNAs
regulatory network
Role of 4-aminobutyrate aminotransferase (ABAT) and the lncRNA co-expression network in the development of myelodysplastic syndrome
期刊论文
ONCOLOGY REPORTS, 2019, 卷号: 42, 期号: 2
作者:
Gu, Jingwen
;
Li, Nianyi
;
Zhao, Guangjie
;
Chen, Yanzhen
;
Luo, Zhongguang
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
myelodysplastic syndrome
4-aminobutyrate aminotransferase
ABAT
long non-coding RNAs
microarray analysis
co-expression network
High methylation of the 4-aminobutyrate aminotransferase gene predicts a poor prognosis in patients with myelodysplastic syndrome
期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2019, 卷号: 54, 期号: 2
作者:
Zhao, Guangjie
;
Li, Nianyi
;
Li, Shuang
;
Wu, Wanling
;
Wang, Xiaoqin
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/05
ABAT gene
DNA methylation
overall survival
myelodysplastic syndrome
Lenalidomide acesulfamate: Crystal structure, solid state characterization and dissolution performance
期刊论文
Journal of Molecular Structure, 2019, 卷号: 1175, 页码: 852-857
作者:
Chen, Xin
;
Li, Duanxiu
;
Wang, Jianming
;
Deng, Zongwu
;
Zhang, Hailu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/11/19
Artificial sweeteners
Intermolecular interactions
Lenalidomide
Myelodysplastic syndromes
Single-crystal and powder
Solid state characterization
Solid-state nuclear magnetic resonance
Solubilization
Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes
期刊论文
CANCER MEDICINE, 2019, 卷号: 8, 期号: 3, 页码: 1169-1174
作者:
Zhao, Baobing
;
Liu, Hui
;
Mei, Yang
;
Liu, Yijie
;
Han, Xu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
chromatin condensation
enucleation
erythropoiesis
myelodysplastic
syndromes
[Consistency Analysis of Gene Mutation Sites of Bone Marrow Tumor DNA and Circulating Tumor DNA in Patients with Myelodysplastic Syndrome].
期刊论文
Zhongguo shi yan xue ye xue za zhi, 2019, 卷号: Vol.27 No.1, 页码: 149-158
作者:
Pan Zhao
;
Qian-Ze Zhu
;
Teng Fan
;
Wei-Yi Liu
;
Hai-Yan Xiao
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/17
Monosomal karyotypes apart from complex karyotypes independently predict the outcome of myelodysplastic syndrome patients using a fluorescence in situ hybridization panel and conventional cytogenetics
期刊论文
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2019, 卷号: 41, 期号: 4, 页码: 519-529
作者:
Wang, Na
;
Xu, Hongzhi
;
Li, Qing
;
Liu, Jie
;
Sui, Xiaohui
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/12/11
cytogenetics
fluorescence in situ hybridization
monosomal karyotype
myelodysplastic syndromes
prognosis
Upregulation of SPAG6 in Myelodysplastic Syndrome: Knockdown Inhibits Cell Proliferation Via AKT/FOXO Signaling Pathway.
期刊论文
DNA and cell biology, 2019
作者:
Mei Jiang
;
Ya Chen
;
Linli Deng
;
Xiaohua Luo
;
Li Wang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/17
AKT/FOXO
SPAG6
cell proliferation
myelodysplastic syndrome
p27Kip1
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