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科研机构
上海药物研究所 [8]
大连化学物理研究所 [2]
深圳先进技术研究院 [1]
中国科学院大学 [1]
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期刊论文 [11]
会议论文 [1]
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2020 [1]
2017 [2]
2016 [1]
2015 [1]
2013 [2]
2012 [1]
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物理化学 [1]
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Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 6
作者:
Hu, Wen-juan
;
Chang, Lu
;
Yang, Ying
;
Wang, Xin
;
Xie, Yuan-chao
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/12/21
remdesivir
pharmacokinetics
tissue distribution
nucleotide monophosphate
nucleotide triphosphate
nucleoside
Identification of human UDP-glucuronosyltransferase isoforms involved in the isofraxidin glucuronidation and assessment of the species differences of the reaction
期刊论文
FITOTERAPIA, 2017, 卷号: 117, 页码: 118-125
作者:
Meng, Fanxing
;
Li, Yan
;
He, Guiyuan
;
Ge, Guangbo
;
Liu, Shumin
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/06/20
Isofraxidin
Udp-glucuronosyltransferases (Ugts)
Human Liver Microsomes (Hlm)
Human Intestinal Microsomes (Him)
Species Differences
Estrogen-Related Receptor α Regulates Hepatic VLDL Secretion
会议论文
浙江杭州, 2017
作者:
Meng Yang
;
Qingli Liu
;
Minyi Zhang
;
Min Guan
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2018/02/02
Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 卷号: 64, 期号: 4, 页码: 326-339
作者:
Chen, Zhixiang
;
Ning, Mengmeng
;
Zou, Qingan
;
Cao, Hua
;
Ye, Yangliang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Takeda G-protein-coupled receptor 5 agonist
bioisostere
microsomal clearance
structure-activity relationship
Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel
期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 10, 页码: 1632-1641
作者:
Liu, Cai
;
Chen, Zhaoqiang
;
Zhong, Kan
;
Li, Liang
;
Zhu, Weiliang
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  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Pharmacokinetics, Metabolism, and Excretion of the Antiviral Drug Arbidol in Humans
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 卷号: 57, 期号: 4, 页码: 1743-1755
作者:
Deng, Pan
;
Zhong, Dafang
;
Yu, Kate
;
Zhang, Yifan
;
Wang, Ting
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2013, 卷号: 168, 期号: 7, 页码: 1687-1706
作者:
Xie, Cen
;
Zhou, Jialan
;
Guo, Zitao
;
Diao, Xingxing
;
Gao, Zhiwei
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  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
famitinib
metabolism
bioactivation
quinone-imine
hepatotoxicity
Metabolic capabilities of cytochrome P450 enzymes in Chinese liver microsomes compared with those in Caucasian liver microsomes
期刊论文
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 卷号: 73, 期号: 2, 页码: 268-284
作者:
Yang, Junling
;
He, Minxia M.
;
Niu, Wei
;
Wrighton, Steven A.
;
Li, Li
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
cytochrome P450
ethnic difference
human liver microsomes
Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes
期刊论文
DRUG METABOLISM AND DISPOSITION, 2011, 卷号: 39, 期号: 9, 页码: 1503-1510
作者:
Kotani, Naoki
;
Maeda, Kazuya
;
Watanabe, Takao
;
Hiramatsu, Mariko
;
Gong, Li-kun
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and Human
期刊论文
drug metabolism and disposition, 2011, 卷号: 39, 期号: 4, 页码: 675-682
作者:
Ma, Xiao-Chi
;
Ning, Jing
;
Ge, Guang-Bo
;
Liang, Si-Cheng
;
Wang, Xiu-Li
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2012/07/09
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