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GM-Pep: A High Efficiency Strategy to De Novo Design Functional Peptide Sequences
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 卷号: 62, 期号: 10, 页码: 2617-2629
作者:
Chen, Qushuo
;
Yang, Changyan
;
Xie, Yihao
;
Wang, Yuqiang
;
Li, Xiaoxu
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/06/21
BioactivityDrug interactionsLearning systemsToxicity
Auto encodersComputation methodsDe novo designFunctional peptidesHigher efficiencyMulti-classifierPeptide sequencesPeptide therapeuticsTherapeutic agentsTherapeutic peptides
Single-Molecule Resettable DNA Computing via Magnetic Tweezers
期刊论文
NANO LETTERS, 2022, 卷号: 22
作者:
Pei, Yufeng
;
Bian, Tianyuan
;
Liu, Yonglin
;
Liu, Yan
;
Xie, Yujie
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2022/12/23
Single-molecule magnetic tweezers
Force-controllable
DNA logic computing
Resettable computing
Toehold-mediated DNA strand displacement
High-throughput fast full-color digital pathology based on Fourier ptychographic microscopy via color transfer
期刊论文
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2021, 卷号: 64, 期号: 11
作者:
Gao, YT
;
Chen, JR
;
Wang, AY
;
Pan, A
;
Ma, CW
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/09/02
computational imaging
Fourier ptychographic microscopy
digital pathology
high throughput
transfer learning
42.30.-d
42.25.Fx
42.30.Rx
Online Active Learning for Drifting Data Streams
期刊论文
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, 2021, 页码: 15
作者:
Liu, Sanmin
;
Xue, Shan
;
Wu, Jia
;
Zhou, Chuan
;
Yang, Jian
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/04/02
Labeling
Data models
Uncertainty
Biological system modeling
Computational modeling
Cognition
Adaptation models
Active learning
concept drift
data stream classification
online incremental learning
Trust Hardware Based Secured Privacy Preserving Computation System for Three-Dimensional Data
期刊论文
ELECTRONICS, 2021, 卷号: 10
作者:
Yuan, Munan
;
Li, Xiaofeng
;
Li, Xiru
;
Tan, Haibo
;
Xu, Jinlin
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/08/31
blockchain
dual hybrid isolation transaction
Ethereum
Intel SGX
privacy
3D data
trusted execution environment
Tuning Convolutional Spiking Neural Network With Biologically Plausible Reward Propagation
期刊论文
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, 2021, 页码: 11
作者:
Zhang, Tielin
;
Jia, Shuncheng
;
Cheng, Xiang
;
Xu, Bo
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/01/27
Neurons
Biology
Convolution
Biological neural networks
Tuning
Membrane potentials
Kernel
Biologically plausible computing
neuronal dynamics
reward propagation
spiking neural network (SNN)
Increasing the Sampling Efficiency of Protein Conformational Change by Combining a Modified Replica Exchange Molecular Dynamics and Normal Mode Analysis
期刊论文
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2021, 卷号: 17, 期号: 1, 页码: 13-28
作者:
Peng, Cheng
;
Wang, Jinan
;
Shi, Yulong
;
Xu, Zhijian
;
Zhu, Weiliang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
Compressed sensing improved iterative reconstruction-reprojection algorithm for electron tomography
期刊论文
BMC BIOINFORMATICS, 2020, 卷号: 21, 页码: 19
作者:
Li, Lun
;
Han, Renmin
;
Zhang, Zhaotian
;
Guo, Tiande
;
Liu, Zhiyong
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2021/12/01
Electron tomography
Compressed sensing
Matching pursuit
Iterative reconstruction-reprojection
Dynamics and stochastic resonance in a thermosensitive neuron
期刊论文
Applied Mathematics and Computation, 2020, 卷号: 385
作者:
Xu, Ying
;
Guo, Yeye
;
Ren, Guodong
;
Ma, Jun
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/11/14
Brain
Circuit resonance
Magnetic resonance
Neurons
Stochastic systems
Thermistors
White noise
Additive Gaussian white noise
Channel conductance
Collective behavior
Physical variables
Scale transformation
Stochastic resonances
Temperature-dependent properties
Time-varying temperatures
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 16, 页码: 6
作者:
Su, Zhicheng
;
Yang, Tingyuan
;
Wang, Jie
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/12/24
EGFR
NSCLC
C797S
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