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Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
Glycogen synthase kinase 3 beta inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 2, 页码: 18
作者:
Zhang, Ning
;
Tian, Yu-Nan
;
Zhou, Li-Na
;
Li, Meng-Zhu
;
Chen, Hua-Dong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
A Pharmacodynamic Evaluation Method Based on Optogenetics and Graphene FETs
会议论文
Jiaxing, China, July 27-31, 2021
作者:
Yang J(杨佳)
;
Zu LP(祖立鹏)
;
Dang D(党丹)
;
Li MY(李梦月)
;
Wang WX(王文学)
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2021/11/27
USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines
期刊论文
FEBS JOURNAL, 2020, 页码: 18
作者:
Wang, Hui
;
Meng, Qian
;
Ding, Yiluan
;
Xiong, Muya
;
Zhu, Mengying
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  |  
浏览/下载:84/0
  |  
提交时间:2020/12/24
colorectal cancer
HDX-MS
inhibitor
USP25
USP28
Vismodegib
Structure‐based pharmacophore models to probe anticancer activity of inhibitors of protein kinase B‐beta (PKB β).
期刊论文
Chemical Biology & Drug Design, 2019, 卷号: Vol.93 No.3, 页码: 325-336
作者:
Akhtar, N.a
;
Jabeen, I.a
;
Jalal, N.b
;
Antilla, J.b
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/11/21
Akt
ligand–protein interactions
phosphoinositide 3‐kinase
quinoline‐type inhibitors
structure‐based pharmacophore modeling
virtual screening
Identification of novel and potent small-molecule inhibitors of tubulin with antitumor activities by virtual screening and biological evaluations
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 7, 页码: 659-664
作者:
Liu, Guangpu
;
Jiao, Yang
;
Huang, Chunxi
;
Chang, Ping
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Microtubules inhibitors
Anticancer target
Colchicine binding site
Drug discovery
Molecular docking
Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters
期刊论文
SCIENTIFIC REPORTS, 2019, 卷号: 9, 期号: 1
作者:
Zhang, Feng
;
Sheng, Hao*
;
Wang, Shuang
;
Ma, Yu
;
Cai, Changqun*
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer
期刊论文
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2019, 卷号: 22, 期号: 2, 页码: 113-122
作者:
Zhang, Xin-Guo
;
Ma, Guo-Yan
;
Fei Kou
;
Liu, Wen-Jie
;
Sun, Qiao-Yun
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/11/15
ADA inhibitors
Reynoutria japonica
cordycepin
lymphoproliferative disorders
anti-cancer therapy
traditional chinese medicine
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:
Wang, Jia
;
Gong, Grace Qun
;
Zhou, Yan
;
Lee, Woo-Jeong
;
Buchanan, Christina Maree
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2019/01/08
high throughput screening
PI3 kinase
PI3K alpha H1047R
inhibitors
molecular modeling
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Wang, Jia
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
Anticancer drug
Phosphatidylinositol 3-kinase
Structure-activity relationship
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