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科研机构
上海中医药大学 [3]
上海药物研究所 [2]
大连化学物理研究所 [2]
上海大学 [2]
过程工程研究所 [1]
山东大学 [1]
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期刊论文 [14]
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2019 [1]
2017 [2]
2016 [2]
2015 [1]
2011 [4]
2010 [1]
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Tetramethylpyrazine attenuates blood-brain barrier disruption in ischemia/ reperfusion injury through the JAK/STAT signaling pathway
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 卷号: 854
作者:
Gong, Pian
;
Zhang, Zhan
;
Zou, Yichun
;
Tian, Qi
;
Han, Shoumeng
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
Tetramethylpyrazine(TMP)
Ischemia/reperfusion (I/R) injury
Blood-brainbarrier (BBB)
JAK/STAT signal pathway
Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance
期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 135, 页码: 34-48
作者:
Zha, Gao-Feng
;
Qin, Hua-Li*
;
Youssif, Bahaa G. M.
;
Amjad, Muhammad Wahab
;
Raja, Maria Abdul Ghafoor
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/04
Epidermal growth factor receptor (EGFR)
BRAF
Focal adhesion kinase (FAK)
Tubulin polymerization
Cancer cell lines
MDR
multidrug resistance
EGFR
epidermal growth factor receptor
EMEA
European Medicines Evaluation Agency
FDA
US Food and Drug Administration
NSCLC
non-small cell lung
FAK
focal adhesion kinase
RTK
receptor tyrosine kinases
MAPK
mitogen-activated protein kinase
ABC
ATP-binding cassette
NF-kB
NF-kappaB
FERM
Four-point-one, ezrin, radixin, moesin
TMP
Ligustrazine or tetramethylpyrazine
Adr
Adriamycin
DRS
death receptors
TFN
tumor necrosis factor
PI
propidium iodide
TKIs
tyrosine kinase inhibitors
FAR
fluorescence activity ratio
HRMS
high resolution mass spectra
TLC
thin layer chromatography
UV
ultraviolet
DMEM
Dulbecco's modified Eagle's medium
DMSO
dimethyl sulfoxide
IBX
2-iodoxybenzoic acid
Tetramethylpyrazine can ameliorate hepatocellular mitochondrial dysfunction by decreasing the inflammatory response and increasing AQP8 protein expression in septic rats
期刊论文
EUROPEAN JOURNAL OF INFLAMMATION, 2017, 卷号: 15, 期号: 3, 页码: 179-191
作者:
Tao, Xiaogen
;
Li, Kun
;
Wang, Jinquan
;
Zhang, Lin
;
Li, Wei
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/11
aquaporin-8
liver
mitochondrial
rat
sepsis
TMP
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappa B, AP-1 and MAPK pathways in human proximal tubular cells
期刊论文
ARCHIVES OF TOXICOLOGY, 2016, 卷号: 90, 期号: 9
作者:
Gong, Xuezhong
;
Ivanov, Vladimir N.
;
Hei, Tom K.
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
Sodium arsenite
Tetramethylpyrazine (TMP)
Nephrotoxicity
Mitochondrial dysfunction
Inducible heme oxygenase-1 (HO-1)
Arsenic response protein 2 (ARS2)
Nuclear factor erythroid derived-2 (Nrf2)
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells
期刊论文
Archives of toxicology, 2016, 卷号: 90, 页码: 2187-2200
作者:
Gong Xuezhong[1]
;
Ivanov Vladimir N[2]
;
Hei Tom K[3]
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/04/26
Arsenic response protein 2 (ARS2)
Inducible heme oxygenase-1 (HO-1)
Mitochondrial dysfunction
Nephrotoxicity
Nuclear factor erythroid derived-2 (Nrf2)
Sodium arsenite
Tetramethylpyrazine (TMP)
Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death
期刊论文
ARCHIVES OF TOXICOLOGY, 2015, 卷号: 89, 期号: 7
作者:
Gong, Xuezhong
;
Ivanov, Vladimir N.
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Sodium arsenite
Tetramethylpyrazine (TMP)
Nephrotoxicity
Mitochondrial dysfunction
Cyclooxygenase-2
Autophagy
Novel Tandem Biotransformation Process for the Biosynthesis of a Novel Compound, 4-(2,3,5,6-Tetramethylpyrazine-1)-4 '-Demethylepipodophyllotoxin
期刊论文
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2011, 卷号: 77, 期号: 9, 页码: 3023-3034
作者:
Tang, Ya-Jie
;
Zhao, Wei
;
Li, Hong-Mei
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2013/11/06
TRUFFLE TUBER-SINENSE
POLYSACCHARIDES PRODUCTION
BIOLOGICAL EVALUATION
GIBBERELLA-FUJIKUROI
ANTICANCER AGENTS
NATURAL-PRODUCTS
CELL-GROWTH
PODOPHYLLOTOXIN
DERIVATIVES
4'-DEMETHYLEPIPODOPHYLLOTOXIN
Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes
期刊论文
LIFE SCIENCES, 2011, 卷号: 88, 期号: 17-18, 页码: 803-809
作者:
Gao, Xin
;
Zhao, Xiao-long
;
Zhu, Yan-hui
;
Li, Xiao-mu
;
Xu, Qiong
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Muscle
Tetramethylpyrazine
Oxidative stress
Mitochondrial dysfunction
Glucose uptake
Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo
期刊论文
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2011, 卷号: 6
作者:
Zhao, Ji-Hui
;
Ji, Li
;
Wang, Hui
;
Chen, Zhi-Qiang
;
Zhang, Yong-Tai
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/05
TMP
microemulsion
EVA membrane
transdermal delivery
pharmacokinetics
brain distribution
Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo
期刊论文
International journal of nanomedicine, 2011, 卷号: 6, 页码: 1611-9
作者:
Zhao Ji-Hui[1]
;
Ji Li[2]
;
Wang Hui[3]
;
Chen Zhi-Qiang[4]
;
Zhang Yong-Tai[5]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/04/30
EVA membrane
TMP
brain distribution
microemulsion
pharmacokinetics
transdermal delivery
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