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Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Survival-Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah(-/-)Rag2(-/-)IL2rg(-/-) Rats
期刊论文
ADVANCED SCIENCE, 2021, 页码: 14
作者:
Zhang, Ludi
;
Ge, Jian-Yun
;
Zheng, Yun-Wen
;
Sun, Zhen
;
Wang, Chenhua
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/11/04
bioreactor
humanized liver
liver xeno-repopulation
pharmacological study
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signal pathway
期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2021, 卷号: 149
作者:
Zhang, Wang
;
Li, Jing-Ya
;
Wei, Xiao-Chen
;
Wang, Qian
;
Yang, Ji-Yang
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/04/26
DBP
PPAR alpha
AMPK
Lipid metabolism
Liver function
A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14
作者:
Wang, Ying
;
Zhu, Yao
;
Niu, Junxing
;
Deng, Qiangqiang
;
Guo, Shimeng
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/12/21
Bile acid analog
NASH
TGR5
Cd36
AMPK alpha
Gandou decoction, a Chinese medicinal formula, in the treatment of hepatic injury by Wnt/beta-catenin pathway regulation in models of Wilson disease
期刊论文
ANNALS OF PALLIATIVE MEDICINE, 2020, 卷号: 9
作者:
Gao, Manli
;
Geng, Hao
;
Wu, Peng
;
Dong, Jianjian
;
Li, Hai
收藏
  |  
浏览/下载:122/0
  |  
提交时间:2020/11/30
Wilson disease (WD)
liver injury
Gandou decoction (GDD)
Wnt/beta-catenin pathway
oxidative stress
Flow field analyses of a porous membrane-separated, double-layered microfluidic chip for cell co-culture
期刊论文
ACTA MECHANICA SINICA, 2020, 页码: 14
作者:
Chen SB(陈深宝)
;
Xue J(薛健)
;
Hu JR(胡锦荣)
;
Ding QH(丁奇寒)
;
Zhou LW(周吕文)
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/08/26
Immersed boundary method
Porous membrane
Wall shear stress
Penetration velocity
Microfluidic chip
Nimesulide increases the aldehyde oxidase activity of humans and rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Zhou, Lei
;
Pang, Xiao-yan
;
Hou, Xiang-yu
;
Liu, Lu
;
Guo, Zi-tao
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
nimesulide
aldehyde oxidase
induction
methotrexate
hepatocytes
pharmacokinetics
drug interaction
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites
期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 15
作者:
Diao, Xingxing
;
Huestis, Marilyn A.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
novel psychoactive substances
NPS
synthetic cannabinoid
SC
metabolism
urinary metabolites
hepatocyte incubation
Microgravity-induced hepatogenic differentiation of rBMSCs on board the SJ-10 satellite
期刊论文
FASEB JOURNAL, 2019, 卷号: 33, 期号: 3, 页码: 4273-4286
作者:
Lv DY(吕东媛)
;
Sun SJ(孙树津)
;
Zhang F(张帆)
;
Luo CH(罗春花)
;
Zheng L
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2019/04/11
mesenchymal stem cells
mechanotransduction
hepatocyte
signaling pathway
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