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Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
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浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
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  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Simultaneous determination of monocrotaline and its N-oxide metabolite in rat plasma using LC-MS/MS: Application to a pharmacokinetic study
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2021, 页码: 7
作者:
Lin, Feifei
;
Pan, Anni
;
Ye, Yang
;
Liu, Jia
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浏览/下载:30/0
  |  
提交时间:2021/08/17
LC-MS
MS
monocrotaline
monocrotaline N-oxide
pharmacokinetics
The engineered biphenyl dioxygenases enhanced the metabolism of dibenzofuran
期刊论文
INTERNATIONAL BIODETERIORATION & BIODEGRADATION, 2021, 卷号: 161, 页码: 9
作者:
Wang, Yuan
;
Sun, Chengcheng
;
Min, Jun
;
Li, Bingjun
;
Li, Junde
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  |  
浏览/下载:60/0
  |  
提交时间:2021/10/20
Dibenzofuran
Burkholderia xenovorans LB400
Biphenyl dioxygenase
Enzyme engineering
Regiospecificity
Biocatalysts
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Isolation and identification of antimicrobial metabolites from sea anemone-derived fungus Emericella sp. SMA01
期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2021, 页码: 10
作者:
Yue, Yang
;
Yu, Huahua
;
Li, Rongfeng
;
Hu, Linfeng
;
Liu, Song
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浏览/下载:55/0
  |  
提交时间:2021/04/14
sea anemone
symbiotic fungi
phenazine-1-carboxylic acid
antimicrobial activity
Safety, Clinical Activity, and Pharmacokinetics of Al flutinib (AST2818) in Patients With Advanced NSCLC With EGFR T790M Mutation
期刊论文
JOURNAL OF THORACIC ONCOLOGY, 2020, 卷号: 15, 期号: 6, 页码: 1015-1026
作者:
Shi, Yuankai
;
Zhang, Shucai
;
Hu, Xingsheng
;
Feng, Jifeng
;
Ma, Zhiyong
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  |  
浏览/下载:38/0
  |  
提交时间:2020/12/24
Alflutinib
NSCLC
EGFR T790M mutation
Efficacy
Safety
Betel quid-associated cancer: Prevention strategies and targeted treatment
期刊论文
CANCER LETTERS, 2020, 卷号: 477, 期号: 0, 页码: 60-69
作者:
Ko, Albert Min-Shan
;
Lee, Chien-Hung
;
Ko, Ying-Chin
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2020/09/15
Detoxification
Carcinogenesis
Chemoprevention
Arecoline N-Oxide
Reactive oxygen species
Nimesulide increases the aldehyde oxidase activity of humans and rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Zhou, Lei
;
Pang, Xiao-yan
;
Hou, Xiang-yu
;
Liu, Lu
;
Guo, Zi-tao
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
nimesulide
aldehyde oxidase
induction
methotrexate
hepatocytes
pharmacokinetics
drug interaction
Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1
期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 卷号: 32, 期号: 10, 页码: 1965-1976
作者:
Yang, Xiao-Nan
;
Wang, Yi-Kun
;
Zhu, Xu
;
Xiao, Xue-Rong
;
Dai, Man-Yun
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  |  
浏览/下载:21/0
  |  
提交时间:2020/03/26
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