Betel quid-associated cancer: Prevention strategies and targeted treatment

doi:10.1016/j.canlet.2020.02.030

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	Betel quid-associated cancer: Prevention strategies and targeted treatment
	Ko, Albert Min-Shan 4; Lee, Chien-Hung 2,3; Ko, Ying-Chin 1,5
刊名	CANCER LETTERS
	2020-05-01
卷号	477 期号:0 页码:60-69
关键词	Detoxification Carcinogenesis Chemoprevention Arecoline N-Oxide Reactive oxygen species
ISSN号	0304-3835
DOI	10.1016/j.canlet.2020.02.030
英文摘要	Betel quid (BQ) and areca nut use are at risk of cancer. This review includes the latest evidence of carcinogenesis caused by BQ exposure, suggests possible prevention strategies. We conducted a systematic literature search in the PubMed and Web of Science databases to identify relevant articles published in the past 10 years according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Arecoline N-oxide, a metabolite of areca nut, is likely an initiator in carcinogenesis and is detoxified by N-acetylcysteine. Oral potentially malignant disorder and reactive oxygen species involved in carcinogenesis pathways may be treatable using antioxidants. Screening programs conducted by trained physicians are useful for identifying patients with early stages of oral cancer in high-risk groups. Anti-inflammatory medications may be used as chemopreventive agents in the disease-free stage after surgery. The association between survival and tumor somatic mutations in patients who chew BQ should be addressed in cancer studies. Current evidence on the natural course from BQ exposure to cancer occurrence and development provides information for developing primary, secondary, and tertiary prevention strategies against BQ-associated cancer at clinical or translational levels.
资助项目	Ministry of Science and Technology[MOST 106-2314-B-039-016-MY3] ; China Medical University Hospital[DMR 109-250]
WOS关键词	SQUAMOUS-CELL CARCINOMA ; ORAL SUBMUCOUS FIBROSIS ; POTENTIALLY MALIGNANT DISORDERS ; ARECOLINE N-OXIDE ; ARECA-CATECHU NUT ; ALCOHOL-CONSUMPTION ; TOBACCO SMOKING ; BUCCAL MUCOSA ; RISK ; SALIVA
WOS研究方向	Oncology
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000525867900007
内容类型	期刊论文
源URL	[http://119.78.100.205/handle/311034/17321]
专题	古脊椎动物与古人类研究所_图书馆1
通讯作者	Ko, Ying-Chin
作者单位	1.China Med Univ, China Med Univ Hosp, Environm Omics Dis Res Ctr, Taichung, Taiwan 2.Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan 3.Kaohsiung Med Univ, Dept Publ Hlth & Res, Ctr Environm Med, Kaohsiung, Taiwan 4.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing, Peoples R China 5.Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan
推荐引用方式 GB/T 7714	Ko, Albert Min-Shan,Lee, Chien-Hung,Ko, Ying-Chin. Betel quid-associated cancer: Prevention strategies and targeted treatment[J]. CANCER LETTERS,2020,477(0):60-69.
APA	Ko, Albert Min-Shan,Lee, Chien-Hung,&Ko, Ying-Chin.(2020).Betel quid-associated cancer: Prevention strategies and targeted treatment.CANCER LETTERS,477(0),60-69.
MLA	Ko, Albert Min-Shan,et al."Betel quid-associated cancer: Prevention strategies and targeted treatment".CANCER LETTERS 477.0(2020):60-69.