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Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Characterization and quantitative determination of henagliflozin metabolites in humans
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 192, 页码: 8
作者:
Chen, Zhendong
;
Li, Liang
;
Zhan, Yan
;
Zhang, Yifan
;
Liu, Haiyan
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  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
Henagliflozin
Metabolism
LC-MS/MS
Pyrrolidinyl Synthetic Cathinones alpha-PHP and 4F-alpha-PVP Metabolite Profiling Using Human Hepatocyte Incubations
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 1, 页码: 17
作者:
Carlier, Jeremy
;
Diao, Xingxing
;
Giorgetti, Raffaele
;
Busardo, Francesco P.
;
Huestis, Marilyn A.
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  |  
浏览/下载:38/0
  |  
提交时间:2021/05/24
alpha-PHP
PV7
4F-alpha-PVP
novel psychoactive substance
synthetic cathinone
bath salt
hepatocyte metabolism
liquid chromatography-high resolution tandem mass spectrometry
UPLC-ESI-Q-TOF/MS Based Metabolic Profiling of Protosappanin B in Rat Plasma, Bile, Feces, Urine and Intestinal Bacteria Samples
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 6, 页码: 491-499
作者:
Chen, Wei-Ying
;
Liang, Guang-Yan
;
Zheng, Zuo-Liang
;
Wu, Yun-Shan
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  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
Protosappanin B
Metabolic pathways
UPLC-TOF-MS
MS
Plasma
Bile
Feces
Urine
Intestinal bacteria sample
Metabolic Profiling of Nuciferine in Vivo and in Vitro
期刊论文
Journal of Agricultural and Food Chemistry, 2020, 卷号: 68, 期号: 48, 页码: 14135-14147
作者:
Gao, Hua
;
Zhang, Lei
;
Zhu, An
;
Liu, Xiaoyan
;
Wang, Tianxia
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  |  
浏览/下载:6/0
  |  
提交时间:2022/02/17
Biomolecules
Enzymes
Mammals
Mass spectrometry
Metabolites
Broad spectrum
Drug formulations
High resolution mass spectrometry
Metabolic characteristics
Metabolic profiling
Molecular docking
Nelumbo nucifera
Recombinant enzymes
Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 12, 页码: 6523-6537
作者:
Zhao, Jihui
;
Cui, Rongrong
;
Wang, Lihao
;
Chen, Yingjia
;
Fu, Zunyun
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  |  
浏览/下载:25/0
  |  
提交时间:2020/12/24
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:
Pan, Lulu
;
Guo, Shuang
;
Chen, Xiaoyan
;
Jiang, Xiangrui
;
Shen, Jingshan
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  |  
浏览/下载:53/0
  |  
提交时间:2020/07/01
TPNI71
Metabolism
UPLC/Q-TOF MS
High-resolution mass spectrometry
Metabolite identification
Effect of ethnicity on vinorelbine pharmacokinetics: a population pharmacokinetics analysis
期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2019, 卷号: 84, 期号: 2, 页码: 373-382
作者:
Petain, Aurelie
;
Zhong, Dafang
;
Chen, Xiaoyan
;
Li, Zhang
;
Shao Zhimin
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  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
Vinorelbine
Non-small-cell lung cancer
Breast cancer
China
Pharmacokinetics
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