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上海药物研究所 [5]
西北高原生物研究所 [2]
苏州纳米技术与纳米仿... [1]
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海洋研究所 [1]
山东大学 [1]
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期刊论文 [16]
学位论文 [1]
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2022 [2]
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Isolation, synthesis and bioactivity evaluation of isoquinoline alkaloids from Corydalis hendersonii Hemsl. against gastric cancer in vitro and in vivo
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 60
作者:
Luo, T
;
Li, Z
;
Deng, XM
;
Jiang, K
;
Liu, D
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2022/12/02
Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 228
作者:
Deng, XM
;
Luo, T
;
Li, Z
;
Wen, HX
;
Zhang, HH
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  |  
浏览/下载:15/0
  |  
提交时间:2022/12/02
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291
作者:
Fan, Lei
;
Qiu, Xiao-xia
;
Zhu, Zhi-yuan
;
Lv, Jian-lu
;
Lu, Jian
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Alzheimer's disease
nitazoxanide
autophagy
inflammation
APP/PS1 transgenic mice
BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
作者:
Guo, Chuanlong
;
Wang, Lijun
;
Zhao, Yue
;
Jiang, Bo
;
Luo, Jiao
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  |  
浏览/下载:117/0
  |  
提交时间:2019/08/28
bromophenol
apoptosis
autophagy
phosphoinositide 3-kinase
protein kinase B
mechanistic target of rapamycin signaling
reactive oxygen species
Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Tang, Qing
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  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Proliferation
Anticancer drug
Phosphatidylinositol 3-kinase inhibitor
Apoptosis
Structure-activity relationship
Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3K alpha-selective inhibitor CYH33 in breast cancer
期刊论文
CANCER LETTERS, 2018, 卷号: 433, 页码: 273-282
作者:
Liu, Xue-ling
;
Xu, Yi-chao
;
Wang, Yu-xiang
;
Chen, Yi
;
Wang, Bo-bo
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  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
PIK3CA
HER2
Akt
Patient-derived xenograft (PDX)
Ghrelin and gastrointestinal stromal tumors
期刊论文
2017, 卷号: 23, 期号: 10, 页码: 1758-1763
作者:
Zhu, Chang-Zhen
;
Liu, Dong
;
Kang, Wei-Ming
;
Yu, Jian-Chun
;
Ma, Zhi-Qiang
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  |  
浏览/下载:1/0
  |  
提交时间:2020/01/04
Gastrointestinal stromal tumor
PI3K/AKT/ mTOR pathway
Ghrelin
Occurrence
Development
Synergism and mechanism of Astragaloside IV combined with Ginsenoside Rg1 against autophagic injury of PC12 cells induced by oxygen glucose deprivation/reoxygenation
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, 卷号: 89, 页码: 124-134
作者:
Huang, Xiao-Ping(黄小平)
;
Ding, Huang
;
Yang, Xiao-Qian
;
Li, Jing-Xian
;
Tang, Biao(唐标)
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/27
Astragaloside IV
Ginsenoside Rg1
Synergism
PC12 cells OGD/R
Autophagic injury
PI3K I/Akt/mTOR
PI3K III/Beclin-1/Bcl-2
RACK1 is required for adipogenesis
期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2016, 卷号: 311, 期号: 5, 页码: C831-C836
作者:
Kong, Qinghua
;
Gao, Lan
;
Niu, Yanfen
;
Gongpan, Pianchou
;
Xu, Yuhui
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2017/02/14
RACK1
3T3-L1
adipogenesis
Wnt
PI3K-Akt-mTOR-S6K
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
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