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Dezocine as a potent analgesic: overview of its pharmacological characterization
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Ye, Rong-Rong
;
Jiang, Shuang
;
Xu, Xu
;
Lu, Yan
;
Wang, Yu-Jun
收藏
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浏览/下载:30/0
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提交时间:2021/12/16
dezocine
opioid receptors
norepinephrine
serotonin transporter
postoperative pain
anesthesia
Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Wei, Yuan-yuan
;
Ma, Yan
;
Yao, Song-yu
;
Kong, Ling-hui
;
Liu, Xiao
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  |  
浏览/下载:40/0
  |  
提交时间:2021/11/04
kappa-opioid receptor agonist
4,5-expoxymorphinan
antinociception
conditioned place aversion
sedation
U50,488H
morphine
Nor-BNI
beta-FNA
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
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浏览/下载:88/0
  |  
提交时间:2021/11/04
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9458-9483
作者:
Huang, Huoming
;
Li, Xueping
;
Xie, Peng
;
Li, Xinwei
;
Xu, XueJun
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  |  
浏览/下载:29/0
  |  
提交时间:2021/08/17
Neurobiological Bases of Social Networks
期刊论文
FRONTIERS IN PSYCHOLOGY, 2021, 卷号: 12, 页码: 17
作者:
Han, Mengfei
;
Jiang, Gaofang
;
Luo, Haoshuang
;
Shao, Yongcong
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浏览/下载:81/0
  |  
提交时间:2021/06/09
social network
social cognition
mentalizing network
multilayer brain-social networks
neural mechanism
The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review
期刊论文
NEURAL PLASTICITY, 2021, 卷号: 2021, 页码: 11
作者:
Wang, Xia-qing
;
Mokhtari, Tahmineh
;
Zeng, Yu-xuan
;
Yue, Lu-peng
;
Hu, Li
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  |  
浏览/下载:23/0
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提交时间:2021/04/30
Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective mu Opioid Receptor Agonists
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 2, 页码: 285-299
作者:
Huang, Huoming
;
Li, Xinwei
;
Guo, Wei
;
Zhu, Chen
;
Qian, Yuanyuan
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  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
pain
opioid analgesic
SAR
selective MOR agonist
molecular dynamics simulations
Molecular mechanisms of fentanyl mediated beta-arrestin biased signaling
期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2020, 卷号: 16, 期号: 4, 页码: 24
作者:
de Waal, Parker W.
;
Shi, Jingjing
;
You, Erli
;
Wang, Xiaoxi
;
Melcher, Karsten
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  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Huang, Huoming
;
Wang, Wenli
;
Xu, Xuejun
;
Zhu, Chen
;
Wang, Yujun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Selective MOR agonists
Antinociception
Analgesic
Opioids
Molecular mechanism
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
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  |  
浏览/下载:92/0
  |  
提交时间:2020/07/01
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