The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review | |
Wang, Xia-qing1,2; Mokhtari, Tahmineh1,2; Zeng, Yu-xuan1,2; Yue, Lu-peng1,2; Hu, Li1,2 | |
刊名 | NEURAL PLASTICITY |
2021-02-22 | |
卷号 | 2021页码:11 |
ISSN号 | 2090-5904 |
DOI | 10.1155/2021/6682275 |
产权排序 | 1 |
文献子类 | 综述 |
英文摘要 | Chronic pain is considered an economic burden on society as it often results in disability, job loss, and early retirement. Opioids are the most common analgesics prescribed for the management of moderate to severe pain. However, chronic exposure to these drugs can result in opioid tolerance and opioid-induced hyperalgesia. On pain modulation strategies, exploiting the multitarget drugs with the ability of the superadditive or synergistic interactions attracts more attention. In the present report, we have reviewed the analgesic effects of different dopamine receptors, particularly D1 and D2 receptors, in different regions of the central nervous system, including the spinal cord, striatum, nucleus accumbens (NAc), and periaqueductal gray (PAG). According to the evidence, these regions are not only involved in pain modulation but also express a high density of DA receptors. The findings can be categorized as follows: (1) D2-like receptors may exert a higher analgesic potency, but D1-like receptors act in different manners across several mechanisms in the mentioned regions; (2) in the spinal cord and striatum, antinociception of DA is mainly mediated by D2-like receptors, while in the NAc and PAG, both D1- and D2-like receptors are involved as analgesic targets; and (3) D2-like receptor agonists can act as adjuvants of mu-opioid receptor agonists to potentiate analgesic effects and provide a better approach to pain relief. |
资助项目 | National Natural Science Foundation of China[32071061] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[32000749] |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | HINDAWI LTD |
WOS记录号 | WOS:000627169900001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38812] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Yue, Lu-peng; Hu, Li |
作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Xia-qing,Mokhtari, Tahmineh,Zeng, Yu-xuan,et al. The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review[J]. NEURAL PLASTICITY,2021,2021:11. |
APA | Wang, Xia-qing,Mokhtari, Tahmineh,Zeng, Yu-xuan,Yue, Lu-peng,&Hu, Li.(2021).The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review.NEURAL PLASTICITY,2021,11. |
MLA | Wang, Xia-qing,et al."The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review".NEURAL PLASTICITY 2021(2021):11. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论