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上海药物研究所 [16]
合肥物质科学研究院 [11]
中国医学科学院 北京... [6]
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期刊论文 [49]
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The effect of EGFR-TKIs on survival in advanced non-small-cell lung cancer with EGFR mutations: A real-world study
期刊论文
CANCER MEDICINE, 2022
作者:
Yu, Xiaoqing
;
Si, Jinfei
;
Wei, Jingwen
;
Wang, Yanling
;
Sun, Yan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/23
EGFR-TKIs
non-small cell lung cancer (NSCLC)
real-world study
survival outcome
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 16, 页码: 6
作者:
Su, Zhicheng
;
Yang, Tingyuan
;
Wang, Jie
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/24
EGFR
NSCLC
C797S
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidines as new reversible inhibitors of EGFR C797S (Cys797 to Ser797) mutant
期刊论文
CHINESE CHEMICAL LETTERS, 2020, 卷号: 31, 期号: 5, 页码: 1281-1287
作者:
Hu, Xianglong
;
Xun, Qiuju
;
Zhang, Tao
;
Zhu, Su-Jie
;
Li, Qian
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  |  
浏览/下载:47/0
  |  
提交时间:2020/07/01
EGFR(C797S) mutant
SARs
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidine
Clinical resistance
Fourth-generation inhibitors
Design and synthesis of selective degraders of EGFR(L858R/T790M) mutant
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 192, 页码: 14
作者:
Zhang, Xin
;
Xu, Fang
;
Tong, Linjiang
;
Zhang, Tao
;
Xie, Hua
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  |  
浏览/下载:81/0
  |  
提交时间:2020/07/01
Epidermal growth factor receptor (EGFR)
Resistance
Proteolysis targeting chimera (PROTAC)
Protein degradation
EGFR exon 20 insertion mutations in non-small cell lung cancer
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2020, 卷号: 9
作者:
Wang, Fenfang
;
Li, Chenghui
;
Wu, Qihuan
;
Lu, Hongyang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/11/26
EGFR exon 20 insertion mutations
non-small cell lung cancer (NSCLC)
EGFR-TKIs
structural features
clinical features
treatment
prognosis
Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFR(L858R/T790M/C797S))
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7302-7308
作者:
Shen, Jiayi
;
Zhang, Tao
;
Zhu, Su-Jie
;
Sun, Min
;
Tong, Linjiang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Prognostic implication of EGFR mutation status and subtype in resected lung adenocarcinoma patients irrespective of therapy
期刊论文
CLINICAL & TRANSLATIONAL ONCOLOGY, 2019, 卷号: 21, 期号: 3, 页码: 298-303
作者:
Li, R.
;
Li, Q.
;
Lin, S.
;
Li, W.
;
Yu, L.
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  |  
浏览/下载:5/0
  |  
提交时间:2019/12/11
Lung adenocarcinoma
EGFR mutation
Prognosis
19del mutation
L858R
mutation
Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma
期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 16, 期号: 6, 页码: 7057-7067
作者:
Li, Ming
;
Li, Chuanying
;
Ke, Li
;
Zhan, Mali
;
Cheng, Min
收藏
  |  
浏览/下载:240/0
  |  
提交时间:2019/06/20
epidermal growth factor receptor
mutation
non-small cell lung cancer
microinvasive adenocarcinoma
molecular subgroup
Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma
期刊论文
Oncology letters, 2018, 卷号: 16, 期号: 6, 页码: 7057-7067
作者:
Li, Ming
;
Li, Chuanying
;
Ke, Li
;
Zhan, Mali
;
Cheng, Min
收藏
  |  
浏览/下载:135/0
  |  
提交时间:2019/05/08
Epidermal growth factor receptor
Mutation
Non-small cell lung cancer
Microinvasive adenocarcinoma
Molecular subgroup
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