Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma

doi:10.3892/ol.2018.9539

	Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma
	Li, Ming 1; Li, Chuanying 1; Ke, Li 3; Zhan, Mali 1; Cheng, Min 2
刊名	ONCOLOGY LETTERS
	2018-12-01
卷号	16 期号:6 页码:7057-7067
关键词	epidermal growth factor receptor mutation non-small cell lung cancer microinvasive adenocarcinoma molecular subgroup
ISSN号	1792-1074
DOI	10.3892/ol.2018.9539
通讯作者	Li, Ming(aylm123@163.com)
英文摘要	Lung microinvasive adenocarcinoma (MIA) is a newly-defined subtype of early stage non-small cell lung cancer (NSCLC). However, its epidermal growth factor receptor (EGFR) mutation status and clinical significance remain unclear. The present study aimed to determine EGFR mutation characteristics and identify their significance in patients with resected lung MIA. The present study also analyzed clinicopathological differences between EGFR molecular subgroups defined as 19Del and L858R. The present study examined EGFR mutations in 79 consecutive lung MIA resection specimens and compared the differences in clinicopathological features between the EGFR wild-type and mutation groups, as well as between the 19Del and L858R subgroups. EGFR mutations were detected in 60 (75.95%) tumors. The most common mutations were 19Del (28 cases; 35.44%) and L858R (30 cases; 37.97%). Two patients harbored rare mutations and one of them had a concomitant double mutation. EGFR mutations were significantly associated with microinvasion component, thyroid transcription factor 1 (TTF-1) expression, intratumoral fibrosis and inflammatory cell infiltration. Subgroup evaluation indicated that there was a significant association between 19Del and tumor size, maximum diameter of microinvasion, presence of intratumoral fibrosis and inflammatory cell infiltration. Similar associations were observed for the L858R subgroup, and L858R was associated with TTF-1 expression. In particular, 19Del occurred more frequently in MIA with a smaller size, with a smaller microinvasive area, without TTF-1 expression, and lacking intratumoral fibrosis and inflammatory cell infiltration. By contrast, L858R was detected more frequently in MIA with entirely different tumor features. In conclusion, the results of the present study indicated that surgically resected MIA cases harboring different EGFR gene statuses exhibit distinct clinicopathological features. Significant differences in pathological features associated with the tumor microenvironment were identified in MIA with 19Del or L858R mutations. Therefore, the present study proposed that MIA should be classified into molecular subgroups based on EGFR mutation subtypes. The molecular sub-classification should be taken into account for prognostic evaluation and clinical management of MIA.
资助项目	National Natural Science Foundation of China[81602605]
WOS关键词	INTERNATIONAL MULTIDISCIPLINARY CLASSIFICATION ; HEALTH-ORGANIZATION CLASSIFICATION ; TRANSCRIPTION FACTOR-I ; EGFR MUTATION ; OPEN-LABEL ; 1ST-LINE TREATMENT ; GENE-MUTATIONS ; PHASE-III ; CLINICOPATHOLOGICAL FEATURES ; CLINICAL-SIGNIFICANCE
WOS研究方向	Oncology
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000451400400020
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166608]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Li, Ming
作者单位	1.Univ Sci & Technol China, Affiliated Hosp 1, Anhui Prov Hosp, Dept Pathol, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China 2.Univ Sci & Technol China, Affiliated Hosp 1, Anhui Prov Hosp, Gerontol Inst Anhui Prov, Hefei 230001, Anhui, Peoples R China 3.Univ Sci & Technol China, Affiliated Hosp 1, Anhui Prov Hosp, Dept Thorac Surg, Hefei 230001, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Li, Ming,Li, Chuanying,Ke, Li,et al. Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma[J]. ONCOLOGY LETTERS,2018,16(6):7057-7067.
APA	Li, Ming,Li, Chuanying,Ke, Li,Zhan, Mali,&Cheng, Min.(2018).Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma.ONCOLOGY LETTERS,16(6),7057-7067.
MLA	Li, Ming,et al."Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma".ONCOLOGY LETTERS 16.6(2018):7057-7067.