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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Safety and Efficacy of D-1553 in Patients with KRAS G12C Mutated Non-Small Cell Lung Cancer: A Phase 1 Trial
期刊论文
JOURNAL OF THORACIC ONCOLOGY, 2022, 卷号: 17
作者:
Lu, S.
;
Jian, H.
;
Zhang, Y.
;
Song, Z.
;
Zhao, Y.
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
Non-small cell lung cancer
KRAS G12C mutation
Small molecular inhibitor
Genomic alterations in biliary tract cancer predict prognosis and immunotherapy outcomes
期刊论文
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 卷号: 9
作者:
Chen, Xiaofeng
;
Wang, Deqiang
;
Liu, Jing
;
Qiu, Jingrong
;
Zhou, Jun
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/01/10
immunotherapy
tumor microenvironment
biomarkers
tumor
genetic markers
Pulmonary enteric adenocarcinoma
期刊论文
TRANSLATIONAL ONCOLOGY, 2021, 卷号: 14
作者:
Gong, Jiali
;
Fan, Ying
;
Lu, Hongyang
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2021/11/01
PEAC
Immunohistochemistry
Mutation analysis
Diagnosis
Prognosis
The genomic landscape of young and old lung cancer patients highlights age-dependent mutation frequencies and clinical actionability in young patients
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2021
作者:
Cai, Lei
;
Chen, Yong
;
Tong, Xiaoling
;
Wu, Xue
;
Bao, Hua
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2021/06/15
EGFR
ERBB2
gene fusions
tyrosine kinase inhibitors
young lung cancer patients
ImmunoAIzer: A Deep Learning-Based Computational Framework to Characterize Cell Distribution and Gene Mutation in Tumor Microenvironment
期刊论文
CANCERS, 2021, 卷号: 13, 期号: 7, 页码: 21
作者:
Bian, Chang
;
Wang, Yu
;
Lu, Zhihao
;
An, Yu
;
Wang, Hanfan
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2021/05/17
deep learning
cell distribution
biomarker
tumor gene mutation
tumor microenvironment (TME)
semi-supervised learning
hematoxylin and eosin (H&
E)
Genomic Profiling and Prognostic Value Analysis of Genetic Alterations in Chinese Resected Lung Cancer With Invasive Mucinous Adenocarcinoma
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 10
作者:
Cai, Lei
;
Wang, Jiangfeng
;
Yan, Junrong
;
Zeng, Jian
;
Zhu, Liang
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/03/15
invasive mucinous adenocarcinoma
surgical resection
next generation sequencing
genomic profiling
prognostic biomarker
Genomic Profiling and Prognostic Value Analysis of Genetic Alterations in Chinese Resected Lung Cancer With Invasive Mucinous Adenocarcinoma
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 10
作者:
Cai, Lei
;
Wang, Jiangfeng
;
Yan, Junrong
;
Zeng, Jian
;
Zhu, Liang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/03/15
invasive mucinous adenocarcinoma
surgical resection
next generation sequencing
genomic profiling
prognostic biomarker
Kras(G12D) mutation contributes to regulatory T cell conversion through activation of the MEK/ERK pathway in pancreatic cancer
期刊论文
CANCER LETTERS, 2019, 卷号: 446
作者:
Fan, Kun
;
Liu, Chen
;
Yu, Xianjun
;
Xu, Jin
;
Jin, Kaizhou
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/05
Pancreatic cancer
Immunosuppressive
Kras(G12D) mutation
IL-10
TGF-beta
Sequential Targeting TGF-beta Signaling and KRAS Mutation Increases Therapeutic Efficacy in Pancreatic Cancer
期刊论文
SMALL, 2019, 卷号: 15, 期号: 24
作者:
Pei, Yuanyuan
;
Chen, Liang
;
Huang, Yukun
;
Wang, Jiahao
;
Feng, Jingxian
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2019/12/05
KRAS
pancreatic cancer
sequential therapy
TGF-beta
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