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复旦大学上海医学院 [12]
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Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 1, 页码: 82-87
作者:
Chen, Yun
;
Ning, Yi
;
Bai, Gang
;
Tong, Linjiang
;
Zhang, Tao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
IRAK4
PROTAC
protein degrader
scaffolding role
diffuse large B-cell lymphoma
Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190, 页码: 14
作者:
Chen, Yun
;
Bai, Gang
;
Ning, Yi
;
Cai, Shi
;
Zhang, Tao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
lnterleukin-1 receptor associated kinase 4
Imidazol1,2-6]pyridazine
Diffuse large B-cell lymphoma
Drug design
Antitumor agents
Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China
期刊论文
BMC CHEMISTRY, 2019, 卷号: 13, 页码: 12
作者:
Gu, Ronghui
;
Wang, Yuehu
;
Wu, Shibiao
;
Wang, Yeling
;
Li, Ping
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/07/29
Tirpitzia sinensis
Linaceae
Lignans
Inflammatory
NO inhibition
Pharmacological targets
Pharmacophore
In silico
Identification, characterisation and preliminary functional analysis of IRAK-M in grass carp (Ctenopharyngodon idella)
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2019, 卷号: 84, 页码: 312-321
作者:
Chu, Pengfei
;
He, Libo
;
Zhu, Denghui
;
Chen, Liangming
;
Huang, Rong
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  |  
浏览/下载:63/0
  |  
提交时间:2019/07/01
Grass carp
IRAK-M
Innate immune
Subcellular localisation
MyD88
下调IRAK1基因调控NF-κB信号通路抑制宫颈癌细胞生长的机制研究
期刊论文
免疫学杂志, 2019, 卷号: 35, 期号: 07
作者:
姜琦
;
陈建翠
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
宫颈癌
IRAK1
NF-κB
TNF-α
Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats
期刊论文
NEUROCHEMICAL RESEARCH, 2019, 卷号: 44, 期号: 5
作者:
Wang, Binbin
;
Zhu, Shunxing
;
Fan, Bingbing
;
Xu, Zhongling
;
Yin, Dekun
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/05
Neuropathic pain (NP)
IRAK1
P-NF-B
Chronic constriction injury (CCI)
MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2019, 卷号: 78
作者:
Chen, Lei
;
Dong, Rui
;
Lu, Yayuan
;
Zhou, Ying
;
Li, Ke
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  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
miR-146a
Postoperative cognitive dysfunction
IRAK1
TRAF6
Pro-inflammatory factors
Microglial activation
MicroRNA-146a Protects Against Cognitive Decline Induced by Surgical Trauma by Suppressing Hippocampal Neuroinflammation In Mice.
期刊论文
Brain, behavior, and immunity, 2019
作者:
Lei Chen
;
Rui Dong
;
Yayuan Lu
;
Ying Zhou
;
Ke Li
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/17
IRAK1
Microglial
activation
Postoperative
cognitive
dysfunction
Pro-inflammatory
factors
TRAF6
miR-146a
MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice
期刊论文
Brain, Behavior, and Immunity, 2019
作者:
Lei Chen
;
Rui Dong
;
Yayuan Lu
;
Ying Zhou
;
Ke Li
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/17
miR-146a
Postoperative
cognitive
dysfunction
IRAK1
TRAF6
Pro-inflammatory
factors
Microglial
activation
March3 attenuates il-1 beta-triggered inflammation by mediating k48-linked polyubiquitination and degradation of il-1ri
期刊论文
Proceedings of the national academy of sciences of the united states of america, 2018, 卷号: 115, 期号: 49, 页码: 12483-12488
作者:
Lin, Heng
;
Gao, Deng
;
Hu, Ming-Ming
;
Zhang, Man
;
Wu, Xiao-Xia
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2019/05/08
March3
Il-1
Listeria monocytogenes
Polyubiquitination
Inflammation
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