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科研机构
上海药物研究所 [14]
大连化学物理研究所 [2]
复旦大学上海医学院 [2]
清华大学 [1]
北京大学 [1]
新疆理化技术研究所 [1]
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期刊论文 [24]
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2021 [2]
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Metabolic Study of Stable Isotope Labeled Indolinone Derivative in Hepatocyte Cell by UPLC/Q TOF MS
期刊论文
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2021, 卷号: 32, 期号: 6, 页码: 1538-1544
作者:
Yang, Jixia
;
Zhang, Gongzheng
;
Wang, Zhaoyang
;
Meng, Jian
;
Wen, Hongliang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/12/16
indolinone derivatives
alpha-synuclein
[C-3(2), N-15]-isotope labeling, metabolite
UPLC/QTOF
Characterization and quantitative determination of henagliflozin metabolites in humans
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 192, 页码: 8
作者:
Chen, Zhendong
;
Li, Liang
;
Zhan, Yan
;
Zhang, Yifan
;
Liu, Haiyan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
Henagliflozin
Metabolism
LC-MS/MS
Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Pan, Lu-lu
;
Yang, Yong
;
Hui, Min
;
Wang, Shuo
;
Li, Cui-yun
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  |  
浏览/下载:82/0
  |  
提交时间:2020/12/24
forsythin
pharmacokinetics
drug metabolism
drug excretion
sulfation
glucuronidation
organic anion transporter 3
A comprehensive study of pomegranate flowers polyphenols and metabolites in rat biological samples by high-performance liquid chromatography quadrupole time-of-flight mass spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2019, 卷号: 1604, 页码: 13
作者:
Yisimayili, Zainaipuguli
;
Abdulla, Rahima
;
Tian, Qiang
;
Wang, Yangyang
;
Chen, Mingcang
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  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Punica granatum L. flowers
Polyphenols
Ellagitannin
Metabolism
HPLC-Q-TOF-MS2
A comprehensive study of pomegranate flowers polyphenols and metabolites in rat biological samples by high-performance liquid chromatography quadrupole time-of-flight mass spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2019, 卷号: 1604, 期号: 10, 页码: 1-13
作者:
Yisimayili, Z (Yisimayili, Zainaipuguli)[ 1,2,3 ]
;
Abdulla, R (Abdulla, Rahima)[ 1 ]
;
Tian, Q (Tian, Qiang)[ 3 ]
;
Wang, YY (Wang, Yangyang)[ 2,3 ]
;
Chen, MC (Chen, Mingcang)[ 3 ]
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  |  
浏览/下载:65/0
  |  
提交时间:2019/11/19
Punica granatum L. flowers
Polyphenols
Ellagitannin
Metabolism
HPLC-Q-TOF-MS2
Simultaneous determination of flavonol glycoside and its major metabolites by LC-MS/MS in rat plasma
期刊论文
Acta Pharmaceutica Sinica, 2018, 卷号: 53, 期号: 8, 页码: 1344-1350
作者:
Dong Lei
;
Liu Jinqiu
;
Li Liang
;
Chen Xiaoyan
;
Shan Weiguang
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  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
LC-MS/MS
flavonol glycoside
glucuronide conjugate
pharmacokinetics
Glucuronide and Sulfate Conjugates of Bisphenol A: Chemical Synthesis and Correlation Between Their Urinary Levels and Plasma Bisphenol A Content in Voluntary Human Donors
期刊论文
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2017
Ho, Ka-Lok
;
Yuen, Ka-Ki
;
Yau, Man-Shan
;
Murphy, Margaret B.
;
Wan, Yi
;
Fong, Bonnie M.W.
;
Tam, Sidney
;
Giesy, John P.
;
Leung, Kelvin S.Y.
;
Lam, Michael H.W.
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
POLYBROMINATED DIPHENYL ETHERS
MASS-SPECTROMETRY
HUMAN EXPOSURE
TETRABROMOBISPHENOL-A
BPA GLUCURONIDE
PREGNANT-WOMEN
UNITED-STATES
MS/MS METHOD
METABOLITES
FETAL
Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate
期刊论文
2016, 卷号: 7, 页码: 242
作者:
Kong, Ling-Lei
;
Shen, Guo-Lin
;
Wang, Zhi-Yuan
;
Zhuang, Xiao-Mei
;
Xiao, Wei-Bin
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/04
thienorphine
multidrug resistance-associated protein 2
P-glycoprotein
biliary excretion
siRNA
drug interaction
A simple method for quantification of tapentadol in dog plasma by liquid chromatography-tandem mass spectrometry and evaluation of the effects of conjugated metabolites on tapentadol
期刊论文
Acta Pharmaceutica Sinica, 2016, 卷号: 51, 期号: 3, 页码: 434-438
作者:
Liang Ge
;
Lu Youming
;
Dai Xiaojian
;
Qin Minjian
;
Zhong Dafang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
LC-MS/MS
LC-MS/MS
tapentadol
conjugated metabolite
pharmacokinetics
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
期刊论文
XENOBIOTICA, 2015, 卷号: 45, 期号: 3, 页码: 270-277
作者:
Yu, Hong
;
Barrass, Nigel
;
Gales, Sonya
;
Lenz, Eva
;
Parry, Tony
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Cynomolgus monkeys
detoxification by glucuronidation
paracetamol toxicity
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