CORC

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CORC

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Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations 期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 卷号: 19, 页码: 3978-3989
作者:  An, Xiaoli;  Bai, Qifeng;  Bing, Zhitong;  Liu, Huanxiang;  Yao, Xiaojun
收藏  |  浏览/下载：12/0  |  提交时间：2021/12/08
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 848-852
作者:  Kong, Deyu;  Guo, Shimeng;  Yang, Yushe;  Guo, Bin;  Xie, Xin
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice 期刊论文
JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214
作者:  Du, Te;  Yang, Liu;  Xu, Xu;  Shi, Xiaofan;  Xu, Xin
收藏  |  浏览/下载：102/0  |  提交时间：2019/01/08
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice 期刊论文
JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: Vol.240 No.2, 页码: 195-214
作者:  Du, Te;  Yang, Liu;  Xu, Xu;  Shi, Xiaofan;  Xu, Xin
收藏  |  浏览/下载：20/0  |  提交时间：2019/12/13
RLA8-A New and Highly Effective Quadruple PPAR-alpha/gamma/delta and GPR40 Agonist to Reverse Nonalcoholic Steatohepatitis and Fibrosis 期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2019, 卷号: 369, 期号: 1, 页码: 67-77
作者:  Li, Meng Hua;  Chen, Wei;  Wang, Li Li;  Sun, Jia Lin;  Zhou, Lei
收藏  |  浏览/下载：73/0  |  提交时间：2019/12/11
RLA8-A New and Highly Effective Quadruple PPAR-α/γ/δ and GPR40 Agonist to Reverse Nonalcoholic Steatohepatitis and Fibrosis 期刊论文
The Journal of pharmacology and experimental therapeutics, 2019, 卷号: 369, 期号: 1, 页码: 67-77
作者:  Li M.H.;  Chen W.;  Wang L.L.;  Sun J.L.;  Zhou L.
收藏  |  浏览/下载：7/0  |  提交时间：2019/12/11
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791
作者:  Guo, Bin;  Guo, Shimeng;  Huang, Jing;  Li, Jingya;  Li, Jia
收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08
Design, synthesis and structure activity relationship studies of GPR40 agonists containing amide linker 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 175-194
作者:  Chen, Tingting;  Ning, Mengmeng;  Ye, Yangliang;  Wang, Kai;  Leng, Ying
收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2697-2717
作者:  Li, He;  Huang, Qi;  Chen, Cheng;  Xu, Bin;  Wang, He-Yao
收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08
Advances in Small-Molecule GPR40 Agonists for Treatment of Type 2 Diabetes Mellitus 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 卷号: 36, 期号: 4, 页码: 736-743
作者:  Li He;  Long Yaqiu
收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08

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