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CORC

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Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:  Hou, Zeng;  Min, Wenjian;  Zhang, Rukang;  Niu, Ao;  Li, Yuanqing
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/01
Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 8, 页码: 1076-1084
作者:  Cao, Yue-peng;  Sun, Jing-ya;  Li, Mei-qian;  Dong, Yu;  Zhang, Yuan-heng
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01
inhibitionofg9abyasmallmoleculeinhibitorunc0642inducesapoptosisofhumanbladdercancercells 期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 8, 页码: 1076
作者:  Cao Yuepeng;  Sun Jingya;  Li Meiqian;  Dong Yu;  Zhang Yuanheng
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01
Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells. 期刊论文
Acta pharmacologica Sinica, 2019, 页码: 1076
作者:  Cao Yuepeng;  Sun Jingya;  Li Meiqian;  Dong Yu;  Zhang Yuanheng
收藏  |  浏览/下载：4/0  |  提交时间：2020/12/24
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search 期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 3
作者:  Ding, Hong;  Lu, Wen Chao;  Hu, Jun Chi;  Liu, Yu-Chih;  Zhang, Chen Hua
收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08
Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 17, 页码: 4579-4594
作者:  Liu, Qing;  Cai, Xiaoqing;  Yang, Dehua;  Chen, Yi;  Wang, Yafang
收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08
Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 122, 页码: 382-393
作者:  Kondengaden, Shukkoor M.;  Luo, Liu-fei;  Huang, Kenneth;  Zhu, Mengyuan;  Zang, Lanlan
收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08
Histone lysine methyltransferases as anti-cancer targets for drug discovery 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1273-1280
作者:  Liu, Qing;  Wang, Ming-wei
收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08
Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver 期刊论文
Chinese Journal of Cancer, 2016, 卷号: 35, 期号: 1, 页码: 491-494
作者:  Liu, Shuang;  Tao, Yong-Guang*
收藏  |  浏览/下载：10/0  |  提交时间：2019/12/03
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation 期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:  Liu, Ke;  Liu, Yanli;  Lau, Johnathan L;  Min, Jinrong*
收藏  |  浏览/下载：13/0  |  提交时间：2019/12/23
Histone demethylation  DNA methylation  Inhibitor  Chemical probe  Drug discovery  LSD  lysine-specific histone demethylase  HDAC  histone deacetylase  REST  REST corepressor  DNMT  DNA methyltransferase  MAO  monoamine oxidase  AML  acute myeloid leukemia  KDM  lysine-specific demethylase  MLL  mixed lineage leukemia  FAD  flavin adenine dinucleotide  PCPA  trans-2-phenylcyclopropylamine  2,4-PDCA  2, 4-pyridinedicarboxylic acid  PHD  plant homeobox domain  SCLC  small cell lung cancer  JHDMs  JmjC-domain-containing histone demethylases  NOG  N-oxalylglycine  IOX1  5-carboxy-8-hydroxyquinoline  MDS  myelodysplastic syndrome  2-OG, 2-oxoglutarate or  α-ketoglutarate  G9a  euchromatic histone-lysine N-methyltransferase 2  CoREST complex  restin corepressor complex  SAH  S-adenosyl-l-homocysteine  l  SWI complex  ATP dependent chromatin remodeling complexes  Pan-Histone Demethylase Inhibitor  the inhibitor can simultaneously inhibit both LSDs and JHDMs  LSC colony  leukemic stem cell colony  Pan JmjC domain-containing demethylase inhibitor  the inhibitor can simultaneously inhibit all the members of JHDMs  E2F1  E2F transcription factor 1  E2F2  E2F transcription factor 2  RCC  renal cell carcinoma  

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