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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Novel HIVEP1-ALK fusion in a patient with lung adenocarcinoma demonstrating sensitivity to alectinib: a case report
期刊论文
TRANSLATIONAL LUNG CANCER RESEARCH, 2022, 卷号: 11
作者:
Gu, Xiaodong
;
Wang, Wenxian
;
Wu, Wei
;
Zhang, Yiping
;
Shao, Lan
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  |  
浏览/下载:13/0
  |  
提交时间:2022/12/22
Non-small cell lung cancer (NSCLC)
HIVEP1-ALK
alectinib
intergenic region (IGR)
case report
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8194-8207
作者:
Du, Daohai
;
Xu, Dandan
;
Zhu, Licheng
;
Stazi, Giulia
;
Zwergel, Clemens
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  |  
浏览/下载:74/0
  |  
提交时间:2021/08/17
Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 16
作者:
Tie, Fangfang
;
Ding, Jin
;
Hu, Na
;
Dong, Qi
;
Chen, Zhi
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  |  
浏览/下载:30/0
  |  
提交时间:2021/11/18
NAFLD
kaempferol
kaempferide
lipid accumulation
oxidative stress
molecular docking
Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes
期刊论文
ENDOCRINE, 2020, 卷号: 67, 期号: 3, 页码: 587-596
作者:
Dou, Hui-Xia
;
Wang, Ting
;
Su, Hai-Xia
;
Gao, Ding-Ding
;
Xu, Ye-Chun
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  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
eFABP4
Adipocyte
Differentiation
Lipolysis
Inflammation
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
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  |  
浏览/下载:94/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells
期刊论文
JOURNAL OF HAZARDOUS MATERIALS, 2019, 卷号: 379, 页码: -
作者:
Sun, Zhendong
;
Yang, Xiaoxi
;
Liu, Qian S.
;
Li, Chuanhai
;
Zhou, Qunfang
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  |  
浏览/下载:35/0
  |  
提交时间:2020/09/10
Butylated hydroxyanisole (BHA) isomers
3T3-L1 cells
Adipogenesis
Lipogenesis
Obesity
Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation
期刊论文
EPIGENETICS & CHROMATIN, 2019, 卷号: 12, 页码: -
作者:
Zhang, Ting
;
Guan, Xiaowen
;
Choi, Un Lam
;
Dong, Qiang
;
Lam, Melody M. T.
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  |  
浏览/下载:26/0
  |  
提交时间:2020/10/21
AMPK
TET2
Phosphorylation
Myogenesis
PAX7
Leptin contributes to the taxol chemoresistance in epithelial ovarian cancer
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 1
作者:
Gu, Fei
;
Zhang, Hao
;
Yao, Liangqing
;
Jiang, Shuheng
;
Lu, Huan
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/12/05
leptin
epithelial ovarian cancer
paclitaxel
chemoresistance
CCAAT
Enhancer Binding Protein alpha
Histone demethylase KDM5A is transactivated by the transcription factor C/EBP and promotes preadipocyte differentiation by inhibiting Wnt/-catenin signaling
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 24
作者:
Tang, Qi-Qun
;
Guo, Liang
;
Guo, Ying-Ying
;
Li, Bai-Yu
;
Peng, Wan-Qiu
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/12/05
adipogenesis
CCAAT
enhancer-binding protein (C
EBP)
histone demethylase
Wnt signaling
beta-catenin (B-catenin)
epigenetics
post-translational modification (PTM)
obesity
chromatin immunoprecipitation (ChiP)
3T3-L1 preadipocyte
adipogenesis
C
EBPbeta
lysine demethylase 5A (KDM5A)
Wnt
beta-catenin pathway
fat cell
ChIP-on-chip
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