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Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Liu, Yi
;
Zhu, Ke-xin
;
Cao, Lei
;
Xie, Zhi-fu
;
Gu, Min
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
berberine
anticancer
membrane permeability
apoptosis
mitochondria
Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes
期刊论文
GUT MICROBES, 2020, 卷号: 11, 期号: 5, 页码: 1348-1361
作者:
Li, Leyuan
;
Chang, Lu
;
Zhang, Xu
;
Ning, Zhibin
;
Mayne, Janice
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  |  
浏览/下载:15/0
  |  
提交时间:2020/12/24
Gut microbiome
functionality
butyrate
Akkermansia
berberine
metaproteomics
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
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  |  
浏览/下载:46/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia
期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:
Wu Chenglin
;
Xi Cong
;
Tong Junhua
;
Zhao Jing
;
Jiang Hualiang
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
DOPAMINE D-1
BERBERINE
EXPRESSION
INHIBITORS
IDENTIFICATION
CHOLESTEROL
MUTATIONS
LDLR
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2 ',3 ': 4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5 '-monophosphate-activated protein kinase (AMPK)
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2017-2027
作者:
Gu, Zhanni
;
Wu, Lingyan
;
Duan, Yanan
;
Wang, Jiang
;
Zhou, Shengbin
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  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Adenosine 5 '-monophosphate-activated protein kinase
AMPK activators
Berberine
Tetrahydroberberine
T2DM
Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy
期刊论文
2018, 卷号: 23, 期号: 8
作者:
Wang, Yan-Xiang
;
Yang, Lu
;
Wang, Hui-Qiang
;
Zhao, Xiao-Qiang
;
Liu, Ting
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/03
enterovirus 71
berberine
structure-activity relationship
MEK
ERK pathway
autophagy
Discovery and Development of 8-Substituted Cycloberberine Derivatives as Novel Antibacterial Agents against MRSA
期刊论文
2018, 卷号: 9, 期号: 5, 页码: 484-489
作者:
Fan, Tianyun
;
Hu, Xinxin
;
Tang, Sheng
;
Liu, Xiaojia
;
Wang, Yanxiang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/01/03
Cycloberberine
berberine
structure-activity relationship
antibacterial
MRSA
Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1
期刊论文
2018, 卷号: 143, 页码: 1858-1868
作者:
Wang, Yan-Xiang
;
Pang, Wei-Qiang
;
Zeng, Qing-Xuan
;
Deng, Zhe-Song
;
Fan, Tian-Yun
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/01/03
Berberine
IDO1
Structure-activity relationship
Cancer immunotherapy
Small-molecule
AMPK
Synthesis and Anticancer Activity of 9-O-Pyrazole Alkyl Substituted Berberine Derivatives.
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2018, 卷号: 18, 期号: 11, 页码: 1639-1648
作者:
Xiao, Daipeng
;
He, Fen
;
Peng, Dongming
;
Zou, Min
;
Peng, Junying
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/27
Berberine
anti-cancer
apoptosis
berberine derivatives
cytotoxicity
oxidative stress.
Berberine Derivatives with Different Pharmacological Activities via Structural Modifications.
期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2018, 卷号: 18, 期号: 17, 页码: 1424-1441
作者:
Xiao, Daipeng
;
Liu, Zhenbao
;
Zhang, Shanshan
;
Zhou, Mi
;
He, Fen
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/27
Berberine
bioavailability
chemical transformation
mechanisms
pharmacological activities
structural modification.
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