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上海药物研究所 [5]
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期刊论文 [18]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML)
期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:
Wu, Jiaxin
;
Wang, Aoli
;
Li, Xixiang
;
Chen, Cheng
;
Qi, Ziping
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/11/27
BCR-ABL
PDGFR
chronic myeloid leukemia
kinase inhibitor
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: Vol.160, 页码: 61-81
作者:
Liu, Xiaochuan
;
Wang, Beilei
;
Wang, Junjie
;
Zhang, Yicong
;
Jiang, Zongru
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/04/24
ABL kinase
Kinase inhibitor
ABL mutant
CML
Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant
期刊论文
2018, 卷号: 9
作者:
Jin, Bei[1,2]
;
Wang, Chengyan[3]
;
Shen, Yingying[3]
;
Pan, Jingxuan[1,2,4]
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/10
Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 122-132
作者:
Liu, Yang
;
Peng, Xia
;
Guan, Xiaocong
;
Lu, Dong
;
Xi, Yong
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
FGFR
KDR
Inhibitor
Anticancer
Ponatinib
Role and Mechanism of the Interaction of BCR-ABL with E3 Ligase c-CBL in Targeting Therapy of Chronic Myelogenous Leukemia
期刊论文
Journal of Experimental Hematology, 2017, 卷号: 25, 期号: 1, 页码: 42-49
作者:
Mao Jianhua
;
Huang Qiuhua
;
Liu Ping
;
Luo Cheng
;
Xi Xiaodong
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
BCR-ABL
c-CBL
BCR-ABL
c-CBL
chronic myelogenous leukemia
arsenic
targeting therapy
Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML)
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 29, 页码: 45562-45574
作者:
Liu, Feiyang
;
Wang, Beilei
;
Wang, Qiang
;
Qi, Ziping
;
Chen, Cheng
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2017/11/21
Bcr-abl
Pdgfr
Chronic Myeloid Leukemia
Kinase Inhibitor
Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 5, 页码: 1984-2004
作者:
Liang, Xiaofei
;
Liu, Xiaochuan
;
Wang, Beilei
;
Zou, Fengming
;
Wang, Aoli
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2017/11/06
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