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Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 14
作者:
Zhao, Yanmei
;
Xu, Lei
;
Zhang, Jiankang
;
Zhang, Mengmeng
;
Lu, Jingyi
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Proteasome inhibitor
Piperidine
Peptidyl
Anti-cancer
SAR
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614
作者:
Dong, Xiao-Wu
;
Zhang, Jian-Kang
;
Xu, Lei
;
Che, Jin-Xin
;
Cheng, Gang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Tripeptide
Covalent docking
Interaction mode
Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 423-439
作者:
Yu, Jianjun
;
Liu, Jieyu
;
Li, Daqiang
;
Xu, Lei
;
Hong, Duidui
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  |  
浏览/下载:0/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Macrocyclic dipeptides
N-Benzyl amides
Metabolic stability
PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 40
作者:
Xia, Tian
;
Yi, Xue-Mei
;
Wu, Xin
;
Shang, Jun
;
Shu, Hong-Bing
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  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
DNA virus
PTPN1
PTPN2
20S proteasome
innate immune response
Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 161, 页码: 543-558
作者:
Yu, Jianjun
;
Xu, Lei
;
Hong, Duidui
;
Zhang, Xiaotuan
;
Liu, Jieyu
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  |  
浏览/下载:71/0
  |  
提交时间:2019/01/08
Proteasome inhibitor
Non-covalent
Non-peptide
Phenol ether
Solid cancers
Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9177-9204
作者:
Li, Daqiang
;
Zhang, Xiaotuan
;
Ma, Xiaodong
;
Xu, Lei
;
Yu, Jianjun
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  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12
作者:
Xu, Yulong
;
Yang, Xicheng
;
Chen, Yiyi
;
Chen, Hao
;
Sun, Huijiao
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Proteasome inhibitors
Topology-based
Scaffold hopping
Bortezomib
Hydrogen sulfide alleviates uranium-induced kidney cell apoptosis mediated by ER stress via 20S proteasome involving in Akt/GSK-3beta/Fyn-Nrf2 signaling.
期刊论文
FREE RADICAL RESEARCH, 2018, 卷号: 52, 期号: 9, 页码: 1020-1029
作者:
Yi, Juan
;
Yuan, Yan
;
Zheng, Jifang*
;
Hu, Nan
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  |  
浏览/下载:5/0
  |  
提交时间:2019/12/27
Apoptosis
ER stress
Nrf2
hydrogen sulfide (H 2 S)
proteasome
uranium
Quantitative proteomic analysis of mosquito c6/36 cells reveals host proteins involved in zika virus infection
期刊论文
Journal of virology, 2017, 卷号: 91, 期号: 12, 页码: 17
作者:
Xin, Qi-Lin
;
Deng, Cheng-Lin
;
Chen, Xi
;
Wang, Jun
;
Wang, Shao-Bo
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/05/08
Zika virus
Quantitative proteomics
Virus-host interaction
Ubiquitin proteasome system
Bortezomib
Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1056-1070
作者:
Zhuang, Rangxiao
;
Gao, Lixin
;
Lv, Xiaoqing
;
Xi, Jianjun
;
Sheng, Li
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Proteasome inhibitors
Piperazine or piperidine
Non-covalent
Peptidyl derivatives
Anti-cancer
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