CORC

浏览/检索结果: 共8条,第1-8条 帮助

限定条件                
已选(0)清除 条数/页:   排序方式:
Broad targeting of triptolide to resistance and sensitization for cancer therapy 期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:  Hou, Zhen-yan;  Tong, Xiao-pei;  Peng, Yong-bo;  Zhang, Bi-Kui*;  Yan, Miao*
收藏  |  浏览/下载:50/0  |  提交时间:2019/12/03
ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells 期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:  Yang, Xin;  Xu, Zhipeng;  Zhang, Chunlan;  Cai, Zixin;  Zhang, Jingjing*
收藏  |  浏览/下载:37/0  |  提交时间:2019/12/03
A1c  glycated hemoglobin  AACE  American Association of Clinical Endocrinologists  ACC  acetyl-CoA carboxylase  ADA  American Diabetes Association  Akt/PKB  tyrosine kinase/protein kinase B  AMP  adenosine monophosphate  AMPK  adenosine monophosphate-activated protein  Ang II  angiotensin II  ATP  adenosine triphosphate  BAT  brown adipose tissue  CHOP  CEBP-homologous protein  CEBP  CCAAT enhancer binding protein  CoA  coenzyme A  DPP  Diabetes Prevention Program  EASD  European Association for the Study of Diabetes  eNOS  endothelial nitric oxide synthase  ER  endoplasmic reticulum  FDA  Food and Drug Administration  FFA  free fatty acid  FOXO1  forkhead box protein O1  G6P  glucose 6-phosphate  GDM  gestational diabetes mellitus  GIPR  glucose-dependent insulinotropic polypeptide receptor  GLP-1R  glucagon-like peptide-1 receptor  GLUT1  glucose transporter-1  GLUT4  glucose transporter type 4  GLUTs  glucose transporters  G6P  glucose 6-phosphate, glucose transporter-1  GPR40  G protein-coupled receptor 40  HbA1c  hemoglobin A1c  HGP  hepatic glucose production  HSL  hormone sensitive lipase  IL-6  interleukin 6  INS-1  insulinoma cells in rat  IR  insulin resistance  IRS-1  insulin receptor substrate 1  JNK  c-Jun. N-terminal kinase  Kir6.2  inwardly rectifying potassium/kalium channel  LDs  lipid droplets  LDL  low density lipoprotein  LV  left ventricular  MIN6 cells  mouse insulinoma cells  MAPK  mitogen-activated protein kinases  mPTP  mitochondrial permeability transition pore opening  mTOR  mammalian target of rapamycin  NADPH  nicotinamide adenine dinucleotide phosphate  NF-kappaB  nuclear factors-kappa B  NIT-1 cells  insulinoma cells  p70S6K  p70 ribosomal S6 kinase  PA  palmitic acid  NOS  NADPH oxidase  p38 MAPK  p38 mitogen-activated protein kinase  PA  palmitic acid  PCOS  polycystic ovary syndrome  PGC-1α  peroxisome proliferator-activated receptor-g coactivator-1α  PI3K  phosphatidylinositol 3-kinase  PKB  protein kinase B  PKC  protein kinase C  PPARα  peroxisome-proliferator activated receptor α  PTP  permeability transition pore  RCT  randomized controlled trial  RISK  reperfusion injury salvage kinase  ROS  reactive oxygen species  SERCA2  reticulum sarcoplasmic Ca2 +-ATPase  RISK  reperfusion injury salvage kinase  Smad3  mothers against decapentaplegic homolog 3  SRC-2  steroid receptor coactivator 2  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TGFβ1  transforming growth factor β1  TLR4  Toll-like receptor  TNF-α  tumor necrosis factor α  TR4  testicular receptor 4  UKPDS  United Kingdom Prospective Diabetes Study  VLDL  very low density lipoprotein  Metformin  Pancreatic β Cells  Heart failure  Insulin sensitizer  
Stauntoside B inhibits macrophage activation by inhibiting NF-κB and ERK MAPK signalling 期刊论文
Pharmacological Research, 2016, 卷号: 111, 期号: Volume 111, 页码: 303-315
作者:  Liu, Jianxin;  Tang, Jinshan;  Zuo, Yihan;  Yu, Yang;  Luo, Pei
收藏  |  浏览/下载:19/0  |  提交时间:2019/12/03
NO  nitric oxide  PGE2  prostaglandin E2  NSAIDs  non-steroidal anti-inflammatory drugs  qRT-PCR  quantitative real-time polymerase chain reaction  LPS  lipopolysaccharide  IFN-γ  interferon γ  G-CSF  granulocyte colony stimulating factor  TNF-α  tumor necrosis factor-α  IL-1β  interleukin-1β  IL-6  interleukin-6  MCP-1  monocyte chemoattractant protein-1  NF-κB  Nuclear factor-κB  IκB  inhibitory protein  IKK  IκB kinase  RPS3  ribosomal protein S3  iNOS  inducible nitric oxide synthase  COX-2  cyclooxygenase-2  PGESs  prostaglandin E2 synthases  mPGES-1  microsomal prostaglandin synthetase-1  mPGES-2  microsomal prostaglandin E synthase-2  cPGES  cytosolic prostaglandin E synthase  MAPK  mitogen-activated protein kinases  ERK  extracellular signal-regulated kinase  JNK  c- Jun N-terminal kinase  PGI2  prostacyclin I2  PGD2  prostaglandin D2  PGF2α  prostaglandin F2α  TXA2  thromboxane A2  Stauntoside B (PubChem CID: 101010462)  Stauntoside B  Cynanchi stauntonii  Lipopolysaccharide  Anti-inflammatory activity  NF-κB  MAPK  
Renoprotective approaches and strategies in acute kidney injury 期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 163, 页码: 58-73
作者:  Yang, Yuan;  Song, Meifang;  Liu, Yu;  Liu, Hong;  Sun, Lin
收藏  |  浏览/下载:20/0  |  提交时间:2019/12/03
ACTH  Adrenocorticotropic hormone  AIF  Apoptosis inducing factor  AKI  Acute kidney injury  BMSC  Bone marrow derived stem cells  CIN  Contrast-induced nephropathy  COMP-Ang1  Cartilage oligomeric matrix protein-angiopoietin-1  CysLT1R  Cysteinyl leukotriene-1 receptor  DMARD  Disease-modifying antirheumatic drugs  eNOS  Endothelial nitric oxide synthase  eEPCs  Endothelial progenitor cells  HDAC  Histone deacetylase  HSPC  Hematopoietic stem and progenitor cells  IRI  Ischemia–reperfusion injury  ICAM-1  Intercellular adhesion molecule-1  JNK  c-Jun N-terminal kinase  KIF3B  Kinesin family member 3B  KIM-1  Kidney injury molecule 1  MAPK  Mitogen-activated protein kinase  MCP-1  Monocyte chemotactic protein-1  α-MSH  Alpha-melanocyte-stimulating hormone  MFG-E8  Milk fat globule-epidermal growth factor-factor VIII  MPT  Mitochondrial permeability transition  MSCs  Mesenchymal stem cells  NGAL  Neutrophil gelatinase-associated lipocalin  MDM2  Murine double minute-2  MMP-2  Matrix metallopeptidase 2  mTOR  Mammalian target of rapamycin  PI3K  Phosphatidylinositol-3 kinase  PACAP  Pituitary adenylate cyclase activating polypeptide  RAAS  Renin–angiotensin–aldosterone system  RANTES  Regulated upon activation normal T-cell expressed and secreted  RIP1  Receptor-interacting protein 1  TNF-α  Tumor necrosis factor-alpha  TWEAK  TNF-like weak inducer of apoptosis  VDRA  Vitamin D receptor agonist  Acute kidney injury  Kidney protection  Kidney repair  Renoprotection  Ischemia–reperfusion  Nephrotoxicity  
Dermatomyositis, polymyositis and immune-mediated necrotising myopathies 期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015, 卷号: 1852, 期号: 4, 页码: 622-632
作者:  Luo, Yue-Bei;  Mastaglia, Frank L
收藏  |  浏览/下载:11/0  |  提交时间:2019/12/03
BAFF  B cell-activating factor  BLTK  B lymphoid tyrosine kinase  CCL21  chemokine (C-C motif) ligand 2  CK  creatine kinase  DC  dendritic cell  CTD  connective tissue disease  DFS70  dense fine speckled 70  DM  dermatomyositis  HIV  human immunodeficiency virus  HLA  human leukocyte antigen  HMGCR  3-hydroxy-3-methyl-glutaryl-CoA reductase  HTLV-1  human T cell leukaemia virus  IBM  inclusion body myositis  IFIH1  interferon induced with helicase C domain protein 1  IL  interleukin  IMNM  immune-mediated necrotising myopathies  INF  interferon  IP-10  INFγ-inducible 10-kD protein  ISG15  IFN-stimulated gene 15  I-TAC  IFN-inducible T cell α chemoattractant  LEDGF  lens epithelium-derived growth factor  MAC  membrane attack complex  MCP-1  monocyte chemoattractant protein-1  MCTD  mixed connective tissue disease  MDA5  melanoma differentiation-associated gene 5  MHC  major histocompatibility complex  MIF  macrophage inhibition factor  MIP-1α  macrophage inflammatory protein 1α  miRNA  microRNA  MxA  myxovirus resistance 1 protein  NuRD  nucleosome remodelling deacetylase complex  NXP-2  nuclear matrix protein 2  pDC  plasmacytoid dendritic cell  PKCε  protein kinase C ε type  PLCL1  phospholipase C like-1  PM  polymyositis  PTPN  protein tyrosine phosphatase N22 gene  SRP  signal recognition particle  RNP  ribonuclear protein complex  TIF  transcription intermediary factor  TLR  Toll like receptor  TNF  tumour necrosis factor  VCAM1  vascular cell adhesion molecule 1  VEGF  vascular endothelial growth factor  Idiopathic inflammatory myopathy  Polymyositis  Dermatomyositis  Immune-mediated necrotising myopathy  Autoantibody  
MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity 期刊论文
Journal of Allergy and Clinical Immunology, 2015, 卷号: 136, 期号: 2, 页码: 462-473
作者:  Li, Jing Jing;  Tay, Hock L.;  Maltby, Steven;  Xiang, Yang;  Eyers, Fiona
收藏  |  浏览/下载:10/0  |  提交时间:2019/12/03
DISC1-related signaling pathways in adult neurogenesis of the hippocampus 期刊论文
Gene, 2013, 卷号: 518, 期号: 2, 页码: 223-230
作者:  Wu, Qian;  Li, Yi;  Xiao, Bo*
收藏  |  浏览/下载:11/0  |  提交时间:2019/12/03
BP  Bipolar disorder  CA  Cornu ammonis  CNS  Central nervous system  CPP  3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid  CT  Carboxyterminal  DG  Dentate gyrus  DGCs  Dentate granule cells  DISC  Disrupted-in-schizophrenia 1  Dixdc1  Dix domain containing 1  FEZ1  Elongation Protein Zeta-1  Fz  Frizzled  GABA  γ-aminobutyric acid  Grb2  Growth factor receptor bound protein 2  GSK3β  Glycogen synthase kinase 3β  KCC2  K+–Cl− co-transporter 2  kDa  kilodalton  KIF5B  Kinesin family members 5B  LEF/TCF  Lymphoid enhancer factor/T cell factor  LIS1  Lissencephaly-1  LRP5/6  Lipoprotein receptor-related protein 5/6  MDD  Major depressive disorder  MK-801  (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]c-cyclohepten-5-10-imine hydrogen maleate  MW  Molecular weight  NDEL1  Nuclear distribution gene E-like homolog 1  NKCC1  Na+-K+-Cl− co-transporter1  NLS  Nuclear localization signal  NMDA-R  N-methyl-d-aspartate-type glutamate receptor  d  NSCs  Neural stem cells  NT  Unique amino  NT-3  Neutrophins-3  OB  Olfactory bulbs  PTEN  Phosphatase and tensin homolog deleted on chromosome ten  RNAi  RNA interference  RYK  Related to tyrosine kinase  SGZ  Subgranular zone  shRNA  Short hairpin RNA  siRNA  Small interference RNA  SVZ  Subventricular zone  SZ  Schizophrenia  DISC1  Signaling pathway  Neurogenesis  DG  Hippocampus  
Hsp20 Protects Neuroblastoma Cells from Ischemia/Reperfusion Injury by Inhibition of Apoptosis via a Mechanism that Involves the Mitochondrial Pathways 期刊论文
Current Neurovascular Research, 2010, 卷号: 7, 期号: 4, 页码: 281-287
作者:  Zeng, Liuwang;  Tan, Jieqiong;  Hu, Zhiping*;  Lu, Wei;  Yang, Binbin
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/03


©版权所有 ©2017 CSpace - Powered by CSpace