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科研机构
上海药物研究所 [156]
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期刊论文 [153]
会议论文 [3]
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2021 [18]
2020 [10]
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Discrete genetic loci in human gutBacteroides thetaiotaomicron confer pectin metabolism
期刊论文
CARBOHYDRATE POLYMERS, 2021, 卷号: 272, 页码: 13
作者:
Li, Meixia
;
Li, Saijuan
;
Guo, Xiaozhen
;
Guo, Ciliang
;
Wang, Yeqin
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/11/04
Polysaccharide
Pectin
Human gut microbiota
Metabolism
Bacteroides
Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator
期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 10, 页码: 2260-2269
作者:
Yin, Jianpeng
;
Zhan, Desheng
;
Ma, Hui
;
Liu, Huanan
;
Yu, Lifang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/12/16
YLF466D
AMPK activator
glucose metabolism
lipid metabolism
MIRI
domino reaction
C-H activation
Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1
期刊论文
Journal of Hematology & Oncology, 2021, 卷号: 14, 期号: 1
作者:
Shi,Zhaopeng
;
Gan,Guifang
;
Xu,Xiang
;
Zhang,Jieying
;
Yuan,Yuan
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/11/04
3-Hydroxyanthronic acid (3-HAA)
Kynurenine
YY1
DUSP6
Hepatocellular carcinoma (HCC)
Tryptophan metabolism
Absorption, distribution, metabolism, and excretion of [C-14]NBP (3-n-butylphthalide) in rats
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 9
作者:
Tian, Junjun
;
Lei, Peng
;
He, Yifei
;
Zhang, Ning
;
Ge, Xinyu
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
3-n-butylphthalide (NBP)
[C-14]NBP
Pharmacokinetics
Tissue distribution
Metabolism
Mass balance
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Liu, Lu
;
Li, Wei
;
Yang, Le
;
Guo, Zi-tao
;
Xue, Hao
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2021/08/17
almonertinib
itraconazole
rifampicin
drug metabolism
drug interaction
CYP3A
P-gp
pharmacokinetics
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa
期刊论文
SCIENCE BULLETIN, 2021, 卷号: 66, 期号: 11, 页码: 1101-1118
作者:
Wang, Yaya
;
Cao, Qiao
;
Cao, Qin
;
Gan, Jianhua
;
Sun, Ning
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
Pseudomonas aeruginosa
Histamine
Metabolism
Host-microbe interaction
Virulence
Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Meng, Jian
;
Zhang, Hua
;
Bao, Jing-jing
;
Chen, Zhen-dong
;
Liu, Xiao-yun
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/06/11
metabolism
mass balance
distribution
covalent binding
furmonertinib
Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Meng, Jian
;
Zhang, Hua
;
Bao, Jing-jing
;
Chen, Zhen-dong
;
Liu, Xiao-yun
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/06/11
metabolism
mass balance
distribution
covalent binding
furmonertinib
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