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科研机构
上海药物研究所 [49]
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期刊论文 [49]
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2021 [1]
2020 [4]
2019 [5]
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Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 4, 页码: 1844-1855
作者:
Zhou, Yu
;
Fu, Yan
;
Yin, Wanchao
;
Li, Jian
;
Wang, Wei
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 20, 页码: 3398-3408
作者:
Liu, Jian-Guo
;
Zhao, Danfeng
;
Gong, Qi
;
Bao, Fengxia
;
Chen, Wen-Wen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Glycogen synthase kinase-3
bisindole-substituted aminopyrazoles
Alzheimer's disease
oxidative neurotoxicity
microglial inflammation
An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy
期刊论文
NATURE BIOMEDICAL ENGINEERING, 2020, 页码: 16
作者:
Wang, Cong
;
Sun, Wanbing
;
Zhang, Jun
;
Zhang, Jianping
;
Guo, Qinghua
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/12/21
Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 3, 页码: 1051-1067
作者:
Hu, Linghao
;
Feng, Hongxuan
;
Zhang, Hongguang
;
Yu, Songda
;
Zhao, Qinyuan
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
advancesinthedevelopmentofimagingprobesandaggregationinhibitorsforalphasynuclein
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 4, 页码: 483
作者:
Xu Mingming
;
Ryan Philip
;
Rudrawar Santosh
;
Quinn Ronald J
;
Zhang Haiyan
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
Parkinson’s disease
alpha-synuclein
imaging probes
aggregation inhibitors
thioflavin-T
mass spectrometry
NLG919/cyclodextrin complexation and anti-cancer therapeutic benefit as a potential immunotherapy in combination with paclitaxel
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 138, 页码: 8
作者:
Xu, Jian
;
Ren, Xiaohong
;
Guo, Tao
;
Sun, Xian
;
Chen, Xiaojin
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Cyclodextrins
NLG919
Solubility enhancement
Paclitaxel
IDO-1 combination immunochemotherapy
Folic acid and its metabolite codetermination for pharmacokinetics with circadian rhythms and evaluation of oral bioavailability
期刊论文
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2019, 页码: 10
作者:
Meng, Fanyue
;
Zhang, Guoqing
;
Wang, Caifen
;
Zhu, Rui
;
Li, Haiyan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
5-methyltetrahydrofolic acid
circadian rhythms
fasted plasma
folic acid
pharmacokinetics
Identification of a New alpha-Synuclein Aggregation Inhibitor via Mass Spectrometry Based Screening
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 6, 页码: 2683-2691
作者:
Xu, Mingming
;
Loa-Kum-Cheung, Wendy
;
Zhang, Haiyan
;
Quinn, Ronald J.
;
Mellick, George D.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Parkinson's disease
alpha-synuclein
aggregation
mass spectrometry
screening
inhibitor
A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of gamma-cyclodextrin metal-organic frameworks
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 卷号: 556, 页码: 89-96
作者:
Xu, Jian
;
Wu, Li
;
Guo, Tao
;
Zhang, Guoqing
;
Wang, Caifen
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
Nanoclusters
gamma-Cyclodextrin metal-organic frameworks
Folic acid
Drug loading
Ship-in-a-Bottle
Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 9, 页码: 2489-2504
作者:
He, Yaping
;
Xu, Jian
;
Sun, Xian
;
Ren, Xiaohong
;
Maharjan, Abi
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
cuboidal cyclodextrin frameworks
shape control
activated platelets
hemostasis
injured vessel targeting
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