An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy

doi:10.1038/s41551-020-00618-4

	An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy
	Wang, Cong 7; Sun, Wanbing 8; Zhang, Jun 9; Zhang, Jianping 1; Guo, Qinghua 7; Zhou, Xingyu 7; Fan, Dandan 7; Liu, Haoran 7; Qi, Ming 1; Gao, Xihui 2
刊名	NATURE BIOMEDICAL ENGINEERING
	2020-09-28
页码	16
ISSN号	2157-846X
DOI	10.1038/s41551-020-00618-4
通讯作者	Mao, Ying(maoying@fudan.edu.cn) ; Li, Cong(congli@fudan.edu.cn)
英文摘要	An intravenously administered electric-field-sensitive contrast agent for magnetic resonance imaging that crosses the blood-brain barrier improves lesion visualization with high sensitivity and target-to-background ratio in mice. For patients with drug-resistant focal epilepsy, excision of the epileptogenic zone is the most effective treatment approach. However, the surgery is less effective in the 15-30% of patients whose lesions are not distinct when visualized by magnetic resonance imaging (MRI). Here, we show that an intravenously administered MRI contrast agent consisting of a paramagnetic polymer coating encapsulating a superparamagnetic cluster of ultrasmall superparamagnetic iron oxide crosses the blood-brain barrier and improves lesion visualization with high sensitivity and target-to-background ratio. In kainic-acid-induced mouse models of drug-resistant focal epilepsy, electric-field changes in the brain associated with seizures trigger breakdown of the contrast agent, restoring the T1-weighted magnetic resonance signal, which otherwise remains quenched due to the distance-dependent magnetic resonance tuning effect between the cluster and the coating. The electric-field-responsive contrast agent may increase the probability of detecting seizure foci in patients and facilitate the study of brain diseases associated with epilepsy.
资助项目	National Natural Science Foundation of China[81771895] ; National Natural Science Foundation of China[81971598] ; National Natural Science Foundation of China[81725009] ; National Natural Science Foundation of China[81501120] ; Shanghai Foundation for Development of Science and Technology[19431900400] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX01] ; Fudan-SIMM Joint Research Fund[20173001] ; Asia 3 Foresight Program[81761148029] ; Shanghai Shuguang Program[19SG06] ; Shanghai Municipal Commission of Health and Family Planning[2017BR003]
WOS关键词	PRESURGICAL EVALUATION ; MRI ; BRAIN ; NANOPARTICLES ; NANOPROBE ; SEIZURE
WOS研究方向	Engineering
语种	英语
出版者	NATURE RESEARCH
WOS记录号	WOS:000573457000002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291257]
专题	中国科学院上海药物研究所
通讯作者	Mao, Ying; Li, Cong
作者单位	1.Fudan Univ, Shanghai Canc Ctr, Dept Nucl Med, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai, Peoples R China 4.Zhejiang Univ, Dept Nucl Med, Sch Med, Hosp 2, Hangzhou, Peoples R China 5.Imperial Coll London, Dept Chem, Mol Sci Res Hub, London, England 6.Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai, Peoples R China 7.Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, Shanghai, Peoples R China 8.Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China 9.Fudan Univ, Inst Funct & Mol Med Imaging, Huashan Hosp, Dept Radiol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Cong,Sun, Wanbing,Zhang, Jun,et al. An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy[J]. NATURE BIOMEDICAL ENGINEERING,2020:16.
APA	Wang, Cong.,Sun, Wanbing.,Zhang, Jun.,Zhang, Jianping.,Guo, Qinghua.,...&Li, Cong.(2020).An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy.NATURE BIOMEDICAL ENGINEERING,16.
MLA	Wang, Cong,et al."An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy".NATURE BIOMEDICAL ENGINEERING (2020):16.