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科研机构
上海药物研究所 [341]
内容类型
期刊论文 [338]
会议论文 [3]
发表日期
2021 [17]
2020 [13]
2019 [13]
2018 [24]
2017 [22]
2016 [26]
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Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site
期刊论文
ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 11, 页码: 2444-2452
作者:
Wang, Jiang
;
Yang, Dehua
;
Cheng, Xi
;
Yang, Linlin
;
Wang, Zhaohui
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/04
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
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  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
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  |  
浏览/下载:17/0
  |  
提交时间:2021/12/16
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Ir(I)-Catalyzed C-H Glycosylation for Synthesis of 2-Indolyl-C-Deoxyglycosides
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2021, 页码: 7
作者:
Yu, Changyue
;
Liu, Yichu
;
Xie, Xiong
;
Hu, Shulei
;
Zhang, Shurui
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/11/04
C-H glycosylation
2-indolyl-C-deoxyglycosides
C-glycosides
Ir(I)-catalyzed
Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2303-2311
作者:
Qu, Ke-Jun
;
Wang, Bin
;
Jiang, Chang-Sheng
;
Xie, Bao-Gang
;
Liu, Ai-Hong
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  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
Direct C4-Acetoxylation of Tryptophan and Tryptophan-Containing Peptides via Palladium(II)-Catalyzed C-H Activation
期刊论文
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 12, 页码: 4699-4704
作者:
Zhang, Qiyu
;
Xie, Xiong
;
Peng, Jingjing
;
Chen, Feiyang
;
Ma, Jinyu
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  |  
浏览/下载:28/0
  |  
提交时间:2021/08/17
Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2021, 页码: 8
作者:
Hu, Shulei
;
Han, Xu
;
Xie, Xiong
;
Fang, Feifei
;
Wang, Yong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/08/17
annulation reactions
C-H activation
pyrazolidinone
Rhodium (III)-catalyzed
sulfoxonium ylide
Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial
期刊论文
FRONTIERS OF MEDICINE, 2021, 页码: 14
作者:
Ni, Li
;
Wen, Zheng
;
Hu, Xiaowen
;
Tang, Wei
;
Wang, Haisheng
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/08/17
COVID-19
SARS-CoV-2
Shuanghuanglian oral liquid
clinical trial
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
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