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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Helix Matrix Transformation Combined With Convolutional Neural Network Algorithm for Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry-Based Bacterial Identification 期刊论文 FRONTIERS IN MICROBIOLOGY, 2020, 卷号: 11, 页码: 10 作者:  Ling, Jin;  Li, Gaomin;  Shao, Hong;  Wang, Hong;  Yin, Hongrui 收藏  |  浏览/下载：124/0  |  提交时间：2020/12/24 matrix-assisted laser desorption ionization-time of flight mass spectrometry  bacterial identification  helix matrix transformation  convolutional neural network  algorithm study   Asperbutenolide A, an unusual aromatic butenolide dimer with diverse bioactivities from a marine-derived fungus Aspergillus terreus SCAU011 期刊论文 TETRAHEDRON LETTERS, 2020, 卷号: 61, 期号: 32, 页码: 6 作者:  Bao, Jie;  Li, Xiu-Xiu;  He, Fei;  Zhang, Xiaoyong;  Zhu, Kongkai 收藏  |  浏览/下载：15/0  |  提交时间：2020/12/24 Aspergillus terreus  Asperbutenolide A  Butyrolactone  Butenolide   Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations 期刊论文 CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 1, 页码: 58-63 作者:  Zhu, Kongkai;  Du, Daohai;  Yang, Rui;  Tao, Hongrui;  Zhang, Hua 收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01 polycomb repressive complex 2  EZH2-EED interaction inhibitor  virtual screening  molecular dynamics simulation   Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations 期刊论文 CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 卷号: 67, 期号: 4, 页码: 382-388 作者:  Tao, Hongrui;  Yan, Xue;  Zhu, Kongkai;  Zhang, Hua 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 virtual screening  epigenetic inhibitor  antiproliferation  molecular docking   Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 317-333 作者:  Shao, Jingwei;  Zhu, Kongkai;  Du, Daohai;  Zhang, Yuanyuan;  Tao, Hongrui 收藏  |  浏览/下载：35/0  |  提交时间：2020/07/01 PRMT5 inhibitors  N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives  Anti-tumor   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   A comparison study between bosentan and enalapril treatment in diabetic nephropathy 期刊论文 Chinese Journal of Nephrology, 2004, 卷号: 20, 期号: 3, 页码: 154-158 作者:  Cheng Hong;  Tian Xuefei;  Dong Hongrui;  Ding Shuangshuang;  Qiu Changbin 收藏  |  浏览/下载：10/0  |  提交时间：2019/01/08 Diabetic nephropathy  Collagen  Transforming growth factor  Connective tissue growth factor-beta1  Bone morphogenetic protein-7