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科研机构
上海药物研究所 [23]
内容类型
期刊论文 [23]
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2021 [3]
2020 [5]
2019 [3]
2018 [5]
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Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance (vol 19, 90, 2020)
期刊论文
MOLECULAR CANCER, 2021, 卷号: 20, 期号: 1, 页码: 1
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/11/04
Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
Molecular Cancer, 2021, 卷号: 20, 期号: 1
作者:
Zhang,Tao
;
Qu,Rong
;
Chan,Shingpan
;
Lai,Mengzhen
;
Tong,Linjiang
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation
期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 7, 页码: 10
作者:
Yang, Jun
;
Wang, Juan
;
Liu, Yuan
;
Zhang, Yu
;
Huang, Wenjing
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/08/17
SOMCL-863, a novel, selective and orally bioavailable small-molecule c-Met inhibitor, exhibits antitumor activity both in vitro and in vivo (vol 351, pg 413, 2014)
期刊论文
CANCER LETTERS, 2020, 卷号: 486, 页码: 71-72
作者:
Wang, Lu
;
Ai, Jing
;
Shen, Yanyan
;
Zhang, Haotian
;
Peng, Xia
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/12/24
Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed
期刊论文
SCIENCE ADVANCES, 2020, 卷号: 6, 期号: 25, 页码: 13
作者:
Fang, Lei
;
Zhao, Zitong
;
Wang, Jue
;
Zhang, Pengcheng
;
Ding, Yaping
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/24
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1, 页码: 15
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer (NSCLC)
EGFR T790M
Small-molecule inhibitor
Drug resistance
Ack1
Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models.
期刊论文
CANCER IMMUNOLOGY RESEARCH, 2020, 卷号: 8, 期号: 3, 页码: 70-70
作者:
Dai, Yang
;
Ji, Yichun
;
Shen, Yanyan
;
Su, Yi
;
Liu, Bo
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
discoveryandbiologicalevaluationofn372methoxy44methylpiperazin1ylphenylamino4methyl2oxo2hpyrimido45d13oxazin14hylphenylacrylamideaspotentbrutonstyrosinekinaseinhibitors
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 415
作者:
Lai Mengzhen
;
Song Peiran
;
Dou Dou
;
Diao Yanyan
;
Tong Linjiang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton’s tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models
期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 卷号: 38, 期号: 1, 页码: 16
作者:
Peng, Xia
;
Hou, Pengcong
;
Chen, Yi
;
Dai, Yang
;
Ji, Yinchun
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Kinase inhibitor
FGFR
CSF-1R
Tumor microenvironment
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
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