Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed

doi:10.1126/sciadv.aba4024

	Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed
	Fang, Lei 2,3,4; Zhao, Zitong 1,2,3; Wang, Jue 2,3; Zhang, Pengcheng 2,3,5; Ding, Yaping 4; Jiang, Yanyan 1; Wang, Dangge 2,3,5; Li, Yaping 2,3,5
刊名	SCIENCE ADVANCES
	2020-06-01
卷号	6 期号:25 页码:13
ISSN号	2375-2548
DOI	10.1126/sciadv.aba4024
通讯作者	Wang, Dangge(dgwang@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要	Autologous tumor cell-based vaccines (ATVs) are emerging as a transformable approach for personalized immunotherapy, but their therapeutic efficacy remains unsatisfying in patients with cancer. Here, we design a photodynamic therapy (PDT)-motivated ATV (P-ATV) in Fmoc-KCRGDK-phenylboronic acid (FK-PBA) hydrogel, which mobilizes local immune activation to inhibit relapse of postoperative tumors. The FK-PBA targeting overexpressed sialic acid on tumor cells can enable on-demand gelation in residue tumor areas and maintain continuous vaccination in surgical bed. Unlike neoantigen-based vaccine or adoptive cell therapy that takes several months to prepare, P-ATV can be easily manufactured within a few days and efficiently boost neoepitope-specific CD8(+) T cells to activate personalized immunotherapy. This simple and powerful approach of engineered ATVs provides an alternative strategy for personalized immunotherapy and is readily transformable to various kinds of cell-based antigens to inhibit the relapse of postoperative tumors.
资助项目	National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81803444] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81903548] ; Strategic Priority Research Program of CAS[XDA12050307] ; Youth Innovation Promotion Association of CAS[2019283] ; Shanghai Sailing Program[19YF1457300]
WOS关键词	CANCER-IMMUNOTHERAPY ; HYPOCHLOROUS ACID ; LYSATE ; MICELLES ; ADJUVANT ; THERAPY
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000542299800020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291746]
专题	中国科学院上海药物研究所
通讯作者	Wang, Dangge; Li, Yaping
作者单位	1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China 5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Fang, Lei,Zhao, Zitong,Wang, Jue,et al. Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed[J]. SCIENCE ADVANCES,2020,6(25):13.
APA	Fang, Lei.,Zhao, Zitong.,Wang, Jue.,Zhang, Pengcheng.,Ding, Yaping.,...&Li, Yaping.(2020).Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed.SCIENCE ADVANCES,6(25),13.
MLA	Fang, Lei,et al."Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed".SCIENCE ADVANCES 6.25(2020):13.