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浏览/检索结果: 共31条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu 收藏  |  浏览/下载：39/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Oxidized Low-Density Lipoprotein Links Hypercholesterolemia and Bladder Cancer Aggressiveness by Promoting Cancer Stemness 期刊论文 CANCER RESEARCH, 2021, 卷号: 81, 期号: 22, 页码: 5720-5732 作者:  Yang, Lin;  Sun, Jingya;  Li, Meiqian;  Long, Yiming;  Zhang, Dianzheng 收藏  |  浏览/下载：23/0  |  提交时间：2022/01/04 Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文 JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14 作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing 收藏  |  浏览/下载：85/0  |  提交时间：2021/08/17 Chaetominine  Cellular growth inhibition  Cancer cell line  Covalent warhead   Constitutive signal bias mediated by the human GHRHR splice variant 1 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10 作者:  Cong, Zhaotong;  Zhou, Fulai;  Zhang, Chao;  Zou, Xinyu;  Zhang, Huibing 收藏  |  浏览/下载：26/0  |  提交时间：2021/12/01 class B1 GPCR  receptor bias  cancer  cell proliferation   A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor 期刊论文 JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8 作者:  Zhou, Jun;  Zhan, Yan;  Zhong, Dafang;  Chen, Xiaoyan;  Zhang, Yifan 收藏  |  浏览/下载：72/0  |  提交时间：2021/11/04 chimmitecan  mass spectrometry  pharmacokinetics  simmitecan  solid tumors   Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ 期刊论文 FRONTIERS IN ENDOCRINOLOGY, 2021, 卷号: 12, 页码: 14 作者:  Yang, Xinyu;  Zhang, Xianfeng;  Yang, Wei;  Yu, Hang;  He, Qianyan 收藏  |  浏览/下载：50/0  |  提交时间：2021/11/04 gut microbiota  adipose tissue dysfunction  molecular endocrinology  cardiovascular disease(s)  gut dysbiosis   Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor 期刊论文 CELL RESEARCH, 2021, 页码: 11 作者:  Ma, Shanshan;  Chen, Yan;  Dai, Antao;  Yin, Wanchao;  Guo, Jia 收藏  |  浏览/下载：24/0  |  提交时间：2021/11/04 Structural insights into ligand recognition and activation of the melanocortin-4 receptor 期刊论文 CELL RESEARCH, 2021, 页码: 13 作者:  Zhang, Huibing;  Chen, Li-Nan;  Yang, Dehua;  Mao, Chunyou;  Shen, Qingya 收藏  |  浏览/下载：34/0  |  提交时间：2021/11/04 BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer 期刊论文 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 14 作者:  Feng, Mei;  Wu, Zhongen;  Zhou, Yan;  Wei, Zhuang;  Tian, Enming 收藏  |  浏览/下载：29/0  |  提交时间：2021/11/04 Enzyme-Activated Prodrug-Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells 期刊论文 ADVANCED FUNCTIONAL MATERIALS, 2021, 页码: 14 作者:  Duan, Nianxiu;  Li, Junjun;  Song, Sha;  Wang, Feng;  Yang, Yiwei 收藏  |  浏览/下载：26/0  |  提交时间：2021/11/04 drug delivery  pancreatic cancer  prodrugs  smart liposomes  tumor-specific vascular promotion