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科研机构
上海药物研究所 [11]
内容类型
期刊论文 [11]
发表日期
2021 [11]
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发表日期:2021
专题:上海药物研究所
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Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Ir(I)-Catalyzed C-H Glycosylation for Synthesis of 2-Indolyl-C-Deoxyglycosides
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2021, 页码: 7
作者:
Yu, Changyue
;
Liu, Yichu
;
Xie, Xiong
;
Hu, Shulei
;
Zhang, Shurui
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/11/04
C-H glycosylation
2-indolyl-C-deoxyglycosides
C-glycosides
Ir(I)-catalyzed
Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2303-2311
作者:
Qu, Ke-Jun
;
Wang, Bin
;
Jiang, Chang-Sheng
;
Xie, Bao-Gang
;
Liu, Ai-Hong
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
Direct C4-Acetoxylation of Tryptophan and Tryptophan-Containing Peptides via Palladium(II)-Catalyzed C-H Activation
期刊论文
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 12, 页码: 4699-4704
作者:
Zhang, Qiyu
;
Xie, Xiong
;
Peng, Jingjing
;
Chen, Feiyang
;
Ma, Jinyu
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/08/17
Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2021, 页码: 8
作者:
Hu, Shulei
;
Han, Xu
;
Xie, Xiong
;
Fang, Feifei
;
Wang, Yong
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/08/17
annulation reactions
C-H activation
pyrazolidinone
Rhodium (III)-catalyzed
sulfoxonium ylide
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 13
作者:
Gao, Feng
;
Chen, Xiaoxu
;
Lu, Junyan
;
Hu, Shulei
;
Xu, Hui
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
Ceramide analogs
AKT inhibitor
MK2206
Colon cancer
Combination therapy
Discovery of New alpha-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation
期刊论文
FRONTIERS IN CHEMISTRY, 2021, 卷号: 9, 页码: 9
作者:
Liu, Shan-Kui
;
Hao, Haifang
;
Bian, Yuan
;
Ge, Yong-Xi
;
Lu, Shengyuan
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/05/24
α
-glycosidase
virtual screening
cytotoxicity
type 2 diabetes
molecular docking
Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Zeng, Peng
;
Hua, Qiu-hong
;
Gong, Jun-yuan
;
Shi, Chang-jie
;
Pi, Xiao-ping
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/05/24
cortical astrocytes
neonatal
neuronal conversion
insulin
heterogeneity
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
期刊论文
THERANOSTICS, 2021, 卷号: 11, 期号: 11, 页码: 5387-5403
作者:
Wang, Jianfeng
;
Wang, Chen
;
Xu, Pan
;
Li, Xiao
;
Lu, Yongning
收藏
  |  
浏览/下载:128/0
  |  
提交时间:2021/05/24
clear cell renal cell carcinoma
protein arginine methyltransferase 1
therapeutic
lipocalin2 (LCN2)
sunitinib
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