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浏览/检索结果: 共29条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters 期刊论文 CHEMICAL SCIENCE, 2021, 卷号: 13, 期号: 1, 页码: 247-256 作者:  Dong, Lei;  Zhang, Min-Yu;  Han, Hai-Hao;  Zang, Yi;  Chen, Guo-Rong 收藏  |  浏览/下载：31/0  |  提交时间：2022/01/18 LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang 收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15111-15125 作者:  Zhang, Huimin;  He, Jixiao;  Hu, Guang;  Zhu, Fei;  Jiang, Hao 收藏  |  浏览/下载：36/0  |  提交时间：2022/01/04 Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation 期刊论文 BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17 作者:  Xie, Hong-Xu;  Zhang, Juan;  Li, Yue;  Zhang, Jin-He;  Liu, Shan-Kui 收藏  |  浏览/下载：69/0  |  提交时间：2021/11/04 Tetrahydrobenzo[b]thiophen-2-yl)urea  alpha-Glucosidase inhibitors  Non-competitive inhibitor  Molecular docking  Anti-hyperglycaemic activity  Type 2 diabetes   NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms 期刊论文 CELL REPORTS, 2021, 卷号: 36, 期号: 7, 页码: 20 作者:  Zhou, Zikai;  He, Guiqin;  Zhang, Xiaoyun;  Lv, Xin;  Zhang, Xiaolin 收藏  |  浏览/下载：67/0  |  提交时间：2021/11/04 PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation 期刊论文 CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 7, 页码: 10 作者:  Yang, Jun;  Wang, Juan;  Liu, Yuan;  Zhang, Yu;  Huang, Wenjing 收藏  |  浏览/下载：43/0  |  提交时间：2021/08/17 Supramolecular Antagonists Promote Mitochondrial Dysfunction 期刊论文 NANO LETTERS, 2021, 卷号: 21, 期号: 13, 页码: 5730-5737 作者:  Li, Mingming;  Song, Yanqiu;  Song, Na;  Wu, Guangyao;  Zhou, Hao 收藏  |  浏览/下载：87/0  |  提交时间：2021/08/17 Self-Assembly  Peptides  Drug Delivery  Mitochondrion-Targeting  Antagonists   Improved functionality of Ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation 期刊论文 NPJ BIOFILMS AND MICROBIOMES, 2021, 卷号: 7, 期号: 1, 页码: 10 作者:  Yao, Mingfei;  Lu, Yanmeng;  Zhang, Ting;  Xie, Jiaojiao;  Han, Shengyi 收藏  |  浏览/下载：66/0  |  提交时间：2021/08/17 The inhibitory effect of 225 frequently-used traditional Chinese medicines for CYP3A4 metabolic enzyme by isoform-specific probe 期刊论文 FITOTERAPIA, 2021, 卷号: 152, 页码: 5 作者:  Wei, Wenlong;  Li, Zhenwei;  Li, Hao-jv;  An, Yaling;  Qu, Hua 收藏  |  浏览/下载：32/0  |  提交时间：2021/08/17 Inhibitory effect  Frequently-used traditional Chinese medicines  Isoform-specific probe   Identification of novel anti-inflammatory Nur77 modulators by virtual screening 期刊论文 BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 7 作者:  Ding, Xiaoyu;  Zhao, Zijie;  Wu, Yue;  Zhang, Hao;  Chen, Kaixian 收藏  |  浏览/下载：46/0  |  提交时间：2021/08/17 Nur77  Binding site evaluation  Virtual Screening  Inflammation