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浏览/检索结果: 共16条，第1-10条 帮助 限定条件 发表日期：2018     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins 期刊论文 Molecules (Basel, Switzerland), 2018, 卷号: 23, 期号: 12 作者:  Zhang, Haoyue;  Wang, Xueping;  Wang, Ting;  Chen, Kaixian;  Wang, Heyao 收藏  |  浏览/下载：77/0  |  提交时间：2019/01/08 Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 281-294 作者:  Xing, Jing;  Zhang, Rukang;  Jiang, Xiangrui;  Hu, Tianwen;  Wang, Xinjun 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma 期刊论文 ONCOGENESIS, 2018, 卷号: 7 作者:  Chen, Wei;  Zhang, Hao;  Chen, Zhifeng;  Jiang, Hao;  Liao, Liping 收藏  |  浏览/下载：108/0  |  提交时间：2019/01/08 Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407 作者:  Lu, Wenchao;  Xiong, Huan;  Chen, Yu;  Wang, Chen;  Zhang, Hao 收藏  |  浏览/下载：138/0  |  提交时间：2019/01/08 Drug discovery  Epigenetics  Histone acetyltransferase  P300/CBP   Artificial intelligence in drug design 期刊论文 SCIENCE CHINA-LIFE SCIENCES, 2018, 卷号: 61, 期号: 10, 页码: 1191-1204 作者:  Zhong, Feisheng;  Xing, Jing;  Li, Xutong;  Liu, Xiaohong;  Fu, Zunyun 收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 drug design  artificial intelligence  deep learning  QSAR  ADME/T   Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654 作者:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao 收藏  |  浏览/下载：38/0  |  提交时间：2019/01/08 Pyrimidylaminoquinoline  Nonnucleoside DOT1L inhibitors  Amino side chains  Mixed-linage leukemia  Histone lysine methyltransferase   Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758 作者:  Song, Yakai;  Li, Linjuan;  Chen, Yantao;  Liu, Jingqiu;  Xiao, Senhao 收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 DOT1L  MLL-rearranged leukemia  AlphaLISA  HTS  Novel inhibitors   Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2 ',3 ': 4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5 '-monophosphate-activated protein kinase (AMPK) 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2017-2027 作者:  Gu, Zhanni;  Wu, Lingyan;  Duan, Yanan;  Wang, Jiang;  Zhou, Shengbin 收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 Adenosine 5 '-monophosphate-activated protein kinase  AMPK activators  Berberine  Tetrahydroberberine  T2DM   Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies 期刊论文 MEDICINAL RESEARCH REVIEWS, 2018, 卷号: 38, 期号: 3, 页码: 914-950 作者:  Zheng, Mingyue;  Zhao, Jihui;  Cui, Chen;  Fu, Zunyun;  Li, Xutong 收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 ADMET  chemical biology  drug design  in silico  lead optimization  molecular dynamics  polypharmacology  virtual screening   Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins 期刊论文 MOLECULES, 2018, 卷号: 23, 期号: 12 作者:  Li, Yiming;  Zhang, Haoyue;  Wang, Xueping;  Wang, Ting;  Chen, Kaixian 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/05 oligomeric proanthocyanidins  P-glycoprotein  hypoglycemic effect  berberine  pharmacokinetics