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科研机构
中南大学 [12]
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期刊论文 [12]
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2018 [1]
2017 [1]
2014 [1]
2013 [1]
2012 [2]
2011 [1]
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Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms
期刊论文
Cancer Treatment Reviews, 2017, 卷号: 54, 页码: 24-33
作者:
Peng, Mei*
;
Darko, Kwame Oteng
;
Tao, Ting
;
Huang, Yanjun
;
Su, Qiongli
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/03
AIs
aromatase inhibitors
AMPK
Adenosine Monophosphate-Activated Protein Kinase
AR
androgen
ATM
Ataxia Telangiectasia Mutated
ATP
Adenosine Triphosphate
BCSS
breast cancer specific survival
CK-MB
Creatine Kinase-MB
CREB1
cAMP Response Element-Binding Protein 1
CSC
cancer stem cell
DFS
disease-free survival
DHFU
dihydrofluorouracil
DPD
dihydropyrimidine dehydrogenase
EpCAM
Epithelial Cell Adhesion Molecule
ER
estrogen
ERCC1
excision repair cross-complementary 1
ERK
extracellular signal-regulated kinases
EZH2
enhancer of zeste homolog 2
FdUMP
fluorodeoxyuridine monophosphate
FdUTP
fluorodeoxyuridine triphosphate
FHC
ferritin heavy chain
FUTP
fluorouridine triphosphate
HbA1C
hemoglobin A1c
HER
Human Epidermal Growth Factor Receptor
HIF-1α
hypoxia-inducible factor-1α
HK
hexokinase
IGF1R
insulin growth factor 1 receptor
LDH
lactate dehydrogenase
MDA
Muscular Dystrophy Association
MMP
Matrix Metallopeptidase
MRP1
multidrug resistance-associated protein 1
mTOR
mammalian target of rapamycin
MTX
methotrexate
NCCN
National Comprehensive Cancer Network
OS
overall survival
pCR
Pathologic Complete Response
PDGFR
platelet-derived growth factor receptors
PFS
progression-free survival
PKA
protein kinase A
PR
progesterone receptor
RFS
relapse-free survival
SOD
superoxide dismutase
TAM
tamoxifen
TCA
tricarboxlic acid
TS
thymidylate synthase
Combination
Mechanisms
Metformin
Chemotherapeutic drugs
Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
期刊论文
Molecular and Cellular Biochemistry, 2014, 卷号: 386, 期号: 1-2, 页码: 63-71
作者:
Qu, Chen
;
Zhang, Weijia
;
Zheng, Guopei
;
Zhang, Zijuan
;
Yin, Jiang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
Breast cancer
Multidrug resistance
Metformin
EMT
Molecular cloning and expression analysis of PDR1-like gene in ginseng subjected to salt and cold stresses or hormonal treatment
期刊论文
Plant Physiology and Biochemistry, 2013, 卷号: 71, 页码: 203-211
作者:
Zhang, Ru
;
Zhu, Jie
;
Cao, Hong-Zhe
;
An, Yan-Ru
;
Huang, Jing-Jia
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/03
ABA
ABC
ATP-binding cassette
CaMV
DIG
Environmental stresses
GFP
Gene expression
Hormones
JA
MDR
MDR-associated protein
MRP
MS
MeJA
Murashige and Skoog
NBD
ORF
PDR
Panax ginseng
Pleiotropic drug resistance transporter
RACE
SA
SAR
TMD
abscisic acid
cauliflower mosaic virus
digoxigenin
green fluorescent protein
jasmonic acid
methyl jasmonate
multidrug resistance
nucleotide binding domain
open reading frame
pleiotropic drug resistance
qRT-RCR
quantitative real-time PCR
rapid-amplification of cDNA end
salicylic acid
systemic acquired resistance
transmembrane domain
Hypoxia-induced increases in A549/CDDP cell drug resistance are reversed by RNA interference of HIF-1α expression
期刊论文
Molecular Medicine Reports, 2012, 卷号: 5, 期号: 1, 页码: 228-232
作者:
Min, Lingfeng
;
Chen, Qiong
;
He, Shuya*
;
Liu, Shenggang
;
Ma, Yun
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/03
small interfering RNA
hypoxia-inducible factor-1 alpha
multidrug resistance-1
multidrug resistance-associated protein
Effects of Astragalus polysaccharides on P-glycoprotein efflux pump function and protein expression in H22 hepatoma cells in vitro
期刊论文
BMC Complementary and Alternative Medicine, 2012, 卷号: 12, 期号: 1, 页码: 94
作者:
Tian, Qing E.
;
Li, Huan De*
;
Yan, Miao
;
Cai, Hua-Lin
;
Tan, Qin-You
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/03
Astragalus polysaccharides
Multidrug resistance
P-glycoprotein
ABCC1 polymorphism Arg723Gln (2168G > A) is associated with lung cancer susceptibility in a Chinese population
期刊论文
Clinical and Experimental Pharmacology and Physiology, 2011, 卷号: 38, 期号: 9, 页码: 632-637
作者:
Yin, Ji-Ye
;
Han, Li-Fang
;
Huang, Qiong
;
Xu, Xiao-Jing
;
Zhou, Hong-Hao
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
ABCC1
drug response
genetic polymorphism
lung cancer
multidrug resistance
multidrug resistance‐associated protein 1
Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance
期刊论文
Biochemical Pharmacology, 2010, 卷号: 79, 期号: 2, 页码: 154-161
作者:
Kuang, Ye-Hong
;
Shen, Tong
;
Chen, Xiang
;
Sodani, Kamlesh
;
Hopper-Borge, Elizabeth
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
TKI
tyrosine kinase inhibitor
EGFR
epidermal growth factor receptor
MDR
multidrug resistance
ABC
ATP-binding cassette
P-gp (ABCB1)
P-glycoprotein
ABCG2
also called BCRP (breast cancer resistance protein)/MXR (mitoxantrone resistance protein)
MRP7 (ABCC10)
multidrug resistance protein 7
HER
human epidermal receptor
Tyrosine kinase inhibitor
EGFR
Lapatinib
Erlotinib
ABC transporters
MRP7/ABCC10
Multidrug resistance
Nilotinib (AMN107, Tasigna®) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
期刊论文
Biochemical Pharmacology, 2009, 卷号: 78, 期号: 2, 页码: 153-161
作者:
Tiwari, Amit K.
;
Sodani, Kamlesh
;
Wang, Si-Rong
;
Kuang, Ye-Hong
;
Ashby, Charles R., Jr.
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/03
MDR
multidrug resistance
ABC
ATP-binding cassette
ABCB1 (P-gp)
P-glycoprotein
ABCG2
also called BCRP (breast cancer resistance protein)/MXR (mitoxantrone resistance protein)
ABCC1 (MRP1)
multidrug resistance protein 1
EGFR
epidermal growth factor receptor
HER
human epidermal receptor
TKI
tyrosine kinase inhibitor
PBS
phosphate-buffered saline
FTC
fumitremorgin C
E217βG
estradiol 17-β-d-glucuronide
d
MX
mitoxantrone
MTX
methotrexate
Nilotinib
ABC transporters
ABCB1
ABCG2
BCR-Abl
Tyrosine kinase inhibitor
Multidrug resistance
Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance
期刊论文
Biochemical Pharmacology, 2009, 卷号: 77, 期号: 6, 页码: 993-1001
作者:
Zhou, Ying
;
Hopper-Borge, Elizabeth
;
Shen, Tong
;
Huang, Xiao-Cong
;
Shi, Zhi
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
MDR
multidrug resistance
ABC
ATP-binding cassette
BCRP/ABCG2/MXR
breast cancer resistance protein
P-gp/MDR1/ABCB1
P-glycoprotein
MRP7/ABCC10
multidrug resistance protein 7
cepharanthine
6′,12′-dimethoxy-2,2′-dimethyl-6,7-[methylenebis(oxy)oxyacan-than]
E217βG
17-β-estradiol-(17-beta-d-glucuronide)
d
VCR
vincristine
VBL
vinblastine
MTT
(3-(4,5-dimethylthiazol-2-yl)-3, 5-diphenylformazan
MRP7
MDR
Cepharanthine
Paclitaxel
E217βG transport
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