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科研机构
上海药物研究所 [85]
内容类型
期刊论文 [84]
会议论文 [1]
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2021 [8]
2020 [2]
2019 [2]
2018 [5]
2017 [2]
2016 [5]
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Chemistry [3]
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Psychiatry [1]
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New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Dezocine as a potent analgesic: overview of its pharmacological characterization
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Ye, Rong-Rong
;
Jiang, Shuang
;
Xu, Xu
;
Lu, Yan
;
Wang, Yu-Jun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
dezocine
opioid receptors
norepinephrine
serotonin transporter
postoperative pain
anesthesia
Fast determination of 16 circulating neurotransmitters and their metabolites in plasma samples of spontaneously hypertensive rats intervened with five different Uncaria
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1179, 页码: 9
作者:
Gao, Lei
;
Zhang, Zijia
;
Feng, Zijin
;
Wei, Wenlong
;
Wu, Wenyong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
Neurotransmitters
LC-MS
Hypertension
Uncaria
Spontaneously hypertensive rats
Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex
期刊论文
CELL RESEARCH, 2021, 页码: 3
作者:
Huang, Sijie
;
Xu, Peiyu
;
Tan, Yangxia
;
You, Chongzhao
;
Zhang, Yumu
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/08/17
TPN672: A Novel Serotonin-Dopamine Receptor Modulator for the Treatment of Schizophrenia
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 378, 期号: 1, 页码: 20-30
作者:
Wang, Yu
;
He, Yang
;
Yang, Feipu
;
Abame, Melkamu Alemu
;
Wu, Chunhui
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/04
Amygdala dynorphin/kappa opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zan, Gui-ying
;
Sun, Xiang
;
Wang, Yu-jun
;
Liu, Rui
;
Wang, Chen-yao
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/08/17
depression
social defeat stress
amygdala
κ
opioid receptor
dynorphin
c-fos
ERK
norBNI
Structural insights into the lipid and ligand regulation of serotonin receptors
期刊论文
NATURE, 2021, 页码: 25
作者:
Xu, Peiyu
;
Huang, Sijie
;
Zhang, Huibing
;
Mao, Chunyou
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus
期刊论文
NEUROSCIENCE LETTERS, 2021, 卷号: 744, 页码: 7
作者:
Abame, Melkamu Alemu
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
Synthetic cannabidiol
Depression
Serotonin
Noradrenaline
Nuclear factor kappa B
Automated design and optimization of multitarget schizophrenia drug candidates by deep learning
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 204, 页码: 16
作者:
Tan, Xiaoqin
;
Jiang, Xiangrui
;
He, Yang
;
Zhong, Feisheng
;
Li, Xutong
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/12/21
Schizophrenia
Multitarget antipsychotic drugs
Recurrent neural network
Multitask deep neural network
Automated drug design
A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts
期刊论文
ACS CENTRAL SCIENCE, 2020, 卷号: 6, 期号: 2, 页码: 213-225
作者:
Zhang, Bingjie
;
Zhao, Simeng
;
Yang, Dehua
;
Wu, Yiran
;
Xin, Ye
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
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