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科研机构
上海药物研究所 [22]
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期刊论文 [22]
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2020 [1]
2019 [2]
2018 [1]
2016 [2]
2015 [2]
2014 [1]
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Chemistry [1]
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Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Ning, Meng-meng
;
Yang, Wen-ji
;
Guan, Wen-bo
;
Gu, Yi-pei
;
Feng, Ying
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
ulcerative colitis
dextran sulfate sodium
dipeptidyl peptidase 4
sitagliptin
glucagon-like peptide-2
GLP-2(3-33)
apoptosis
proliferation
Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 511, 期号: 2, 页码: 387-393
作者:
Zhang, Hanyan
;
Sun, Dandan
;
Wang, Guanzhen
;
Cui, Shichao
;
Field, Robert A.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
DPP4
Alogliptin
Liver fibrosis
Hepatic stellate cell
Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 5, 页码: 2348-2361
作者:
Li, Shiliang
;
Qin, Chun
;
Cui, Shichao
;
Xu, Hongling
;
Wu, Fangshu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases
期刊论文
Drug metabolism and disposition: the biological fate of chemicals, 2018
作者:
Kong, Fandi
;
Pang, Xiaoyan
;
Zhao, Jihui
;
Deng, Pan
;
Zheng, Mingyue
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
Design, Synthesis of Lithocholic Acid Mimics and Their Inhibitory Activities against Protein Tyrosine Phosphatase 1B
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 卷号: 36, 期号: 11, 页码: 2670-2676
作者:
He Haibing
;
Dai Hong
;
Gao Lixin
;
Zhang Haijun
;
Zou Zheng
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
PTP1B inhibitor
steroid
lithocholic acid mimics
synthesis
Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 14, 页码: 6772-6790
作者:
Li, Shiliang
;
Xu, Hongling
;
Cui, Shichao
;
Wu, Fangshu
;
Zhang, Youli
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Design, Synthesis, and Pharmacological Evaluation of Highly Potent and Selective Dipeptidyl Peptidase-4 Inhibitors
期刊论文
ARCHIV DER PHARMAZIE, 2015, 卷号: 348, 期号: 6, 页码: 399-407
作者:
Jiang, Tao
;
Zhou, Yuren
;
Zhu, Jianming
;
Chen, Zhuxi
;
Sun, Peng
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
beta-Homophenylalanine
DPP-4
Drug design
Inhibitors
P2-binding moiety
Design, Synthesis, and Pharmacological Evaluation of Fused beta-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 6, 期号: 5, 页码: 602-606
作者:
Jiang, Tao
;
Zhou, Yuren
;
Chen, Zhuxi
;
Sun, Peng
;
Zhu, Jianming
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Diabetes
DPP-4 inhibitor
beta-homophenylalanine derivatives
sitagliptin
(R)-3-Amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modeling
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 23, 页码: 6684-6693
作者:
Wang, Sinan
;
Su, Mingbo
;
Wang, Jiang
;
Li, Zeng
;
Zhang, Lei
收藏
  |  
浏览/下载:108/0
  |  
提交时间:2019/01/08
DPP-4
Type 2 diabetes
Inhibitor
Binding mode
Oral bioavailability
Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 23, 页码: 7418-7429
作者:
Wang, Jiang
;
Feng, Ying
;
Ji, Xun
;
Deng, Guanghui
;
Leng, Ying
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Pyrrolidine-2-carbonitrile
4-Fluoropyrrolidine-2-carbonitrile
Dipeptidyl peptidase-4 inhibitor
Oral glucose tolerance test
Type 2 diabetes
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