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科研机构
上海药物研究所 [13]
内容类型
期刊论文 [13]
发表日期
2018 [1]
2017 [1]
2016 [1]
2014 [1]
2009 [4]
2007 [2]
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专题:上海药物研究所
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HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1 alpha promoter
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 卷号: 85, 页码: 126-138
作者:
Xu, Xin
;
Shi, Xiaofan
;
Chen, Yidi
;
Zhou, Tingting
;
Wang, Jiaying
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
T2DM
Gluconeogenesis
FXR antagonist
PGC-1 alpha
Drug lead compound
Design, Synthesis, and Structure-Activity Relationships of Bavachinin Analogues as Peroxisome Proliferator-Activated Receptor Agonists
期刊论文
CHEMMEDCHEM, 2017, 卷号: 12, 期号: 2, 页码: 183-193
作者:
Du, Guoxin
;
Zhao, Yuanyuan
;
Feng, Li
;
Yang, Zhuo
;
Shi, Jiye
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
bavachinin
diabetes mellitus
PPAR
reporter gene assays
structure-activity relationships
Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice
期刊论文
DIABETOLOGIA, 2016, 卷号: 59, 期号: 6, 页码: 1276-1286
作者:
Feng, Li
;
Luo, Huan
;
Xu, Zhijian
;
Yang, Zhuo
;
Du, Guoxin
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
Alternative binding site
Bavachinin
Canonical ligand-binding pocket
Carbohydrate metabolism
Lipid metabolism
Pan-PPAR agonist
Synergistic effects
Activity-guided isolation of NF-kappa B inhibitors and PPAR gamma agonists from the root bark of Lycium chinense Miller
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2014, 卷号: 152, 期号: 3, 页码: 470-477
作者:
Xie, Lian-Wu
;
Atanasov, Atanas G.
;
Guo, De-An
;
Malainer, Clemens
;
Zhang, Jing-Xian
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Lycium chinense Miller
Lycii Radicis Cortex
NF-kappa B
PPAR gamma
Phenolic amides
Fatty acids
7-Chloroarctinone-b as a new selective PPAR gamma antagonist potently blocks adipocyte differentiation
期刊论文
ACTA PHARMACOLOGICA SINICA, 2009, 卷号: 30, 期号: 9, 页码: 1351-1358
作者:
Li, Yong-tao
;
Li, Li
;
Chen, Jing
;
Hu, Tian-cen
;
Huang, Jin
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
peroxisome proliferator-activated receptor
antagonist
surface plasmon resonance
recruitment of the coactivator
adipocyte differentiation
The Role of Tanshinone IIA in the Treatment of Obesity through Peroxisome Proliferator-Activated Receptor gamma Antagonism
期刊论文
ENDOCRINOLOGY, 2009, 卷号: 150, 期号: 1, 页码: 104-113
作者:
Gong, Zhenwei
;
Huang, Cheng
;
Sheng, Xiaoyan
;
Zhang, Yuebo
;
Li, Qunyi
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
7chloroarctinonebasanewselectivepparantagonistpotentlyblocksadipocytedifferentiation
期刊论文
actapharmacologicasinica, 2009, 卷号: 30, 期号: 9, 页码: 1351
作者:
Yongtao LI
;
Li LI
;
Jing CHEN
;
Tiancen HU
;
Jin HUANG
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
peroxisome proliferator-activated receptor
antagonist
surface plasmon resonance
recruitment of the coactivator
adipocyte differentiation
7-Chloroarctinone-b as a new selective PPARγ antagonist potently blocks adipocyte differentiation
期刊论文
Acta Pharmacologica Sinica, 2009, 卷号: 30, 期号: 9, 页码: 1351
作者:
Yongtao LI
;
Li LI
;
Jing CHEN
;
Tiancen HU
;
Jin HUANG
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/12/24
peroxisome proliferator-activated receptor
antagonist
surface plasmon resonance
recruitment of the coactivator
adipocyte differentiation
The potential insulin sensitizing and glucose lowering effects of a novel indole derivative in vitro and in vivo
期刊论文
PHARMACOLOGICAL RESEARCH, 2007, 卷号: 56, 期号: 4, 页码: 335-343
作者:
Li, Ying-Yin
;
Wu, Hao-Shu
;
Tang, Lei
;
Feng, Chu-Rui
;
Yu, Juan-Hong
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
GY3
insulin sensitizing
adipocytokines
antidiabetes
Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor alpha/gamma agonist on glucose uptake
期刊论文
DIABETOLOGIA, 2007, 卷号: 50, 期号: 5, 页码: 1048-1057
作者:
Hu, X.
;
Feng, Y.
;
Liu, X.
;
Zhao, X. -F.
;
Yu, J. -H.
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
adipose tissue
diet-induced obesity
glucose uptake
insulin sensitivity
insulin signalling
peroxisome proliferator-activated receptors
skeletal muscle
thiazolidinediones
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