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科研机构
上海药物研究所 [23]
内容类型
期刊论文 [23]
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2021 [2]
2020 [3]
2018 [2]
2017 [2]
2016 [2]
2015 [1]
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Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge
期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2021, 卷号: 17, 期号: 9, 页码: 19
作者:
Xiong, Zhaoping
;
Jeon, Minji
;
Allaway, Robert J.
;
Kang, Jaewoo
;
Park, Donghyeon
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/11/04
Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells
期刊论文
GENOMICS, 2021, 卷号: 113, 期号: 3, 页码: 1057-1069
作者:
Liu, Yuwei
;
Xue, Mengzhu
;
Cao, Danyan
;
Qin, Lihuai
;
Wang, Ying
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/08/17
Multi-omics
BET inhibitor responses
WNT pathway
Liver cancer
Precise therapy
Revelation of AbfR in regulation of mismatch repair and energy metabolism in S. epidermidis by integrated proteomic and metabolomic analysis
期刊论文
JOURNAL OF PROTEOMICS, 2020, 卷号: 226, 页码: 10
作者:
Gu, Lei
;
Liu, Xing
;
Wang, Yu-Qiu
;
Zhou, Yan-ting
;
Zhu, Hong-wen
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/21
Staphylococcus epidermidis
AbfR transcription factor
Oxidation-sensing regulator
Oxidative stress
TMT10-plex labelling
Antibiotic resistance regulator
Revelation of AbfR in regulation of mismatch repair and energy metabolism in S. epidermidis by integrated proteomic and metabolomic analysis
期刊论文
JOURNAL OF PROTEOMICS, 2020, 卷号: 226, 页码: 10
作者:
Gu, Lei
;
Liu, Xing
;
Wang, Yu-Qiu
;
Zhou, Yan-ting
;
Zhu, Hong-wen
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/21
Staphylococcus epidermidis
AbfR transcription factor
Oxidation-sensing regulator
Oxidative stress
TMT10-plex labelling
Antibiotic resistance regulator
A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 348-357
作者:
Yan, Xiao-xia
;
Li, Hai-long
;
Zhang, Yi-ting
;
Wu, Shou-yan
;
Lu, Heng-lei
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/07/01
manganese superoxide dismutase
5-fluorouracil
chemotherapy
intestinal mucositis
diarrhea
oxidative stress
cytokines
intestinal microbes
SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 243-250
作者:
Jiang, Xi-fei
;
Dai, Yang
;
Peng, Xia
;
Shen, Yan-yan
;
Su, Yi
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
human cancer
anticancer drug
SOMCL-085
receptor tyrosine kinase
FGFR
xenograft nude mouse model
Pyramidatine (Z88) Sensitizes Vincristine-Resistant Human Oral Cancer (KB/VCR) Cells to Chemotherapeutic Agents by Inhibition of P-glycoprotein
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2018, 卷号: 18, 期号: 2, 页码: 286-294
作者:
Liu, Zulong
;
Zhu, Hengrui
;
Qu, Shijin
;
Tang, Lisha
;
Cao, Lihuan
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Aglaia perviridis
multi-drug resistance
KB/VCR cells
P-gp
reversal agent
pyramidatine
A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
期刊论文
POLYMERS, 2017, 卷号: 9, 期号: 10
作者:
Cai, Deqin
;
Yao, Yanli
;
Tang, Yubo
;
Wang, Zheng
;
Shi, Wei
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2019/01/08
arabinogalactan
pancreatic cancer
gemcitabine resistance
carbohydrate chemistry
Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 122-132
作者:
Liu, Yang
;
Peng, Xia
;
Guan, Xiaocong
;
Lu, Dong
;
Xi, Yong
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
FGFR
KDR
Inhibitor
Anticancer
Ponatinib
Enhanced conformational sampling technique provides an energy landscape view of large-scale protein conformational transitions
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2016, 卷号: 18, 期号: 42, 页码: 29170-29182
作者:
Shao, Qiang
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  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
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