A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study

doi:10.3390/polym9100536

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 生物技术药物研发中心（筹）

	A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
	Cai, Deqin 2,3; Yao, Yanli 2,3; Tang, Yubo 1,5; Wang, Zheng 2,4; Shi, Wei 1,3; Huang, Wei 1,3; Ding, Kan2,3
刊名	POLYMERS
	2017-10
卷号	9 期号:10
关键词	arabinogalactan pancreatic cancer gemcitabine resistance carbohydrate chemistry
ISSN号	2073-4360
DOI	10.3390/polym9100536
文献子类	Article
英文摘要	RN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synthesized via [3+2] or [2+2] strategies, efficiently. Two pentasaccharides, 18 and 27, showed similar inhibition effect on pancreatic cancer BxPC-3 cells to that of RN1 at same concentration. Interestingly, tetrasaccharide 21 potently inhibited gemcitabineresistant cell line Panc-1 at high concentration. These suggest that the branches of RN1 might be the active targeting domain and tetrasaccharide 21 might be a potential leading compound for pancreatic cancer with gemcitabine resistance.
资助项目	New Drug Creation and Manufacturing Program[2017ZX09305-003] ; Ministry of Science and Technology, the People Republic of China[00000000] ; State Key Program of National Natural Science Foundation of China[31230022] ; Program of Shanghai Subject Chief Scientist[16XD1404500] ; Innovation Drug Institute of Chinese Academy of Sciences[CASIMM0120154024] ; National Natural Science Foundation of China (NSFC)[31670814]
WOS关键词	CELL-GROWTH ; INHIBITOR ; GLYCOSYLATION
WOS研究方向	Polymer Science
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000414913800074
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272461]
专题	生物技术药物研发中心（筹）药理学第三研究室
通讯作者	Ding, Kan
作者单位	1.Chinese Acad Sci, CAS Key Lab Receptor Res, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 4.Univ Sci & Technol China, Nano Sci & Technol Inst, 96 Jin Zhai Rd, Hefei 230026, Anhui, Peoples R China 5.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China;
推荐引用方式 GB/T 7714	Cai, Deqin,Yao, Yanli,Tang, Yubo,et al. A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study[J]. POLYMERS,2017,9(10).
APA	Cai, Deqin.,Yao, Yanli.,Tang, Yubo.,Wang, Zheng.,Shi, Wei.,...&Ding, Kan.(2017).A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study.POLYMERS,9(10).
MLA	Cai, Deqin,et al."A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study".POLYMERS 9.10(2017).