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科研机构
上海药物研究所 [8]
内容类型
期刊论文 [8]
发表日期
2020 [1]
2018 [3]
2013 [2]
2000 [1]
1999 [1]
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Recent advances in dopaminergic strategies for the treatment of Parkinson's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Mao, Qi
;
Qin, Wang-zhi
;
Zhang, Ao
;
Ye, Na
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Parkinson's disease
dopamine
D-1 receptor
D-2 receptor
allosteric modulator
neuroprotection
multitarget
drug discovery and development
neurodegenerative diseases
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents
期刊论文
ACS chemical neuroscience, 2018
作者:
Xu, Yixiang
;
Zhang, Jian
;
Wang, Huan
;
Mao, Fei
;
Bao, Keting
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 33-47
作者:
Xu, Yi-xiang
;
Wang, Huan
;
Li, Xiao-kang
;
Dong, Sheng-nan
;
Liu, Wen-wen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
MAO-B inhibitors
Metal chelating agents
Alzheimer's disease
Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 13, 页码: 3697-3699
作者:
Guo, Bin
;
Fan, Houxing
;
Xin, Qisheng
;
Chu, Wenjing
;
Wang, Hui
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Benzoxazinyl-oxazolidinone
Linezolid
Antibacterial agents
Gram-positive organisms
Structural Analysis of a Novel Cyclohexylamine Oxidase from Brevibacterium oxydans IH-35A
期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 3
作者:
Mirza, I. Ahmad
;
Burk, David L.
;
Xiong, Bing
;
Iwaki, Hiroaki
;
Hasegawa, Yoshie
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Amyloid-beta 25-35 peptide induces expression of monoamine oxidase B in cultured rat astrocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2000, 卷号: 21, 期号: 6, 页码: 557-563
作者:
Song, W
;
Zhou, LJ
;
Zheng, SX
;
Zhu, XZ
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Alzheimer disease
astrocytes
amyloid beta-protein
monoamine oxidase
monoamine oxidase inhibitors
oxidative stress
The amphetamine-like reinforcing effect and mechanism of L-deprenyl on conditioned place preference in mice
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 卷号: 364, 期号: 1, 页码: 1-6
作者:
Wu, WR
;
Zhu, XZ
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
L-deprenyl
L-amphetamine
reinforcement
haloperidol
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
dopamine
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