The amphetamine-like reinforcing effect and mechanism of L-deprenyl on conditioned place preference in mice

doi:10.1016/S0014-2999(98)00831-0

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	The amphetamine-like reinforcing effect and mechanism of L-deprenyl on conditioned place preference in mice
	Wu, WR; Zhu, XZ
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	1999
卷号	364 期号:1 页码:1-6
关键词	L-deprenyl L-amphetamine reinforcement haloperidol MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopamine
ISSN号	0014-2999
DOI	10.1016/S0014-2999(98)00831-0
文献子类	Article
英文摘要	The present study investigated the reinforcing effect of L-deprenyl on conditioned place preference in mice and its mechanism. Conditioned place preference was induced by 10 and 25 mg/kg L-deprenyl in a dose-dependent fashion during five consecutive conditioning days, and its reinforcing property was about five-fold less potent than that of L-amphetamine. Pretreatment with the dopamine antagonist, haloperidol (1 mg/kg i.p.), effectively blocked the place preference produced by L-deprenyl (10 and 25 mg/kg i.p.) and L-amphetamine (2 and 5 mg/kg i.p.), but haloperidol itself produced no place aversion. The neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 30 mg/kg did not modify the place preference induced by both L-deprenyl and L-amphetamine, though the dopamine concentration in striata assayed by high performance liquid chromatography with electrochemical detection (HPLC-EC) was significantly reduced. These results suggest that L-deprenyl has amphetamine-like reinforcing properties. The reinforcing effect of L-deprenyl may be mediated by central dopaminergic neuronal systems, while the nigrostriatal dopaminergic pathway is not involved. (C) 1999 Elsevier Science B.V. All rights reserved.
WOS关键词	MONOAMINE-OXIDASE ; PARKINSONS-DISEASE ; DOPAMINE UPTAKE ; MAO-B ; SELEGILINE ; RATS ; INHIBITORS ; COCAINE ; DISCRIMINATION ; NEUROTOXICITY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000077909900001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274771]
专题	药理学第二研究室
通讯作者	Zhu, XZ
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Wu, WR,Zhu, XZ. The amphetamine-like reinforcing effect and mechanism of L-deprenyl on conditioned place preference in mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,1999,364(1):1-6.
APA	Wu, WR,&Zhu, XZ.(1999).The amphetamine-like reinforcing effect and mechanism of L-deprenyl on conditioned place preference in mice.EUROPEAN JOURNAL OF PHARMACOLOGY,364(1),1-6.
MLA	Wu, WR,et al."The amphetamine-like reinforcing effect and mechanism of L-deprenyl on conditioned place preference in mice".EUROPEAN JOURNAL OF PHARMACOLOGY 364.1(1999):1-6.