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科研机构
上海药物研究所 [50]
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期刊论文 [50]
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2021 [2]
2020 [2]
2019 [4]
2018 [8]
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Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2
期刊论文
BLOOD ADVANCES, 2021, 卷号: 5, 期号: 1, 页码: 185-197
作者:
Wu, Wenjun
;
Wang, Weige
;
Franzen, Carrie A.
;
Guo, Hui
;
Lee, Jimmy
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  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
Small molecules targeting the innate immune cGAS-STING-TBK1 signaling pathway
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 12, 页码: 2272-2298
作者:
Ding, Chunyong
;
Song, Zilan
;
Shen, Ancheng
;
Chen, Tingting
;
Zhang, Ao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
Immunotherapy
Anti-tumor
cGAS
STING
TBK1
Small molecule modulators
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate
期刊论文
FASEB JOURNAL, 2020, 页码: 18
作者:
Hait, Nitai C.
;
Maiti, Aparna
;
Xu, Pan
;
Qi, Qianya
;
Kawaguchi, Tsutomu
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  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
hypoxia-inducible factors
sphingosine-1-phosphate
sphingosine kinase 2
triple-negative breast cancer
Isolation and structural characterization of a pectin from Lycium ruthenicum Murr and its anti-pancreatic ductal adenocarcinoma cell activity
期刊论文
CARBOHYDRATE POLYMERS, 2019, 卷号: 223, 页码: 10
作者:
Zhang, Shihai
;
He, Fei
;
Chen, Xia
;
Ding, Kan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Rhamnogalacturonan I (RG-I)
Polysaccharide
Lycium ruthenicum Murr
Pancreatic cancer
DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
期刊论文
EPIGENETICS & CHROMATIN, 2019, 卷号: 12, 期号: 1, 页码: 22
作者:
Chen, Ling
;
Shi, Ying
;
Liu, Na
;
Wang, Zuli
;
Yang, Rui
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
LSH
P53
DUB
PKM2
Lipid metabolism
Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal -actinin-4 expression and stabilizing integrin-cytoskeleton linkage
期刊论文
ARTHRITIS RESEARCH & THERAPY, 2019, 卷号: 21, 页码: 16
作者:
He, Shijun
;
Liu, Xing
;
Lin, Zemin
;
Liu, Yuting
;
Gu, Lei
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
SAHH inhibitor
Lupus nephritis
-Actinin-4
Integrin-linked kinase
Integrin
Focal adhesion
Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage
期刊论文
Arthritis Research & Therapy, 2019, 卷号: 21, 期号: 1
作者:
He,Shijun
;
Liu,Xing
;
Lin,Zemin
;
Liu,Yuting
;
Gu,Lei
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/07/01
SAHH inhibitor
Lupus nephritis
α-Actinin-4
Integrin-linked kinase
Integrin
Focal adhesion
Iron-induced energy supply deficiency and mitochondrial fragmentation in neurons
期刊论文
Journal of neurochemistry, 2018, 卷号: 147, 期号: 6, 页码: 816-830
作者:
Huang, Xiao Tian
;
Liu, Xing
;
Ye, Chun Yan
;
Tao, Ling Xue
;
Zhou, Hu
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2019/01/08
Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 10, 页码: 1622-1632
作者:
Zhang, Mei
;
Xie, Zhi-fu
;
Zhang, Run-tao
;
Chen, Da-kai
;
Gu, Min
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
non-alcoholic fatty liver disease
AMP-activated protein kinase
AMPK activator
homogeneous time-resolved fluorescence
metabolic disorders
ob/ob mice
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