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科研机构
上海药物研究所 [409]
内容类型
期刊论文 [398]
项目 [9]
会议论文 [2]
发表日期
2021 [64]
2020 [59]
2019 [31]
2018 [36]
2017 [27]
2016 [33]
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浏览/检索结果:
共409条,第1-10条
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GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhang, Qing
;
Chen, Lin-hai
;
Yang, Hui
;
Fang, You-chen
;
Wang, Si-wei
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/01/18
GPR84
medium chain fatty acid receptor
GPCR
inflammatory bowel diseases
ulcerative colitis
NLRP3 inflammasome
macrophages
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 17
作者:
Li, Xinzhi
;
Yuan, Bingchuan
;
Lu, Min
;
Wang, Yuqin
;
Ding, Na
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/01/18
Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages
期刊论文
PHYTOCHEMISTRY, 2021, 卷号: 192, 页码: 10
作者:
Wang, Qiaoqiao
;
Zhang, Tian
;
Ke, Chang-Qiang
;
Tang, Chunping
;
Yao, Sheng
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/12/01
Artemisia codonocephala
Asteraceae
Guaianolides
Anti-inflammation
IL-1 beta
NLRP3
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Chen, Cheng
;
Ren, Yong-mei
;
Zhu, Jian-zhong
;
Chen, Jia-li
;
Feng, Zhe-ling
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2022/01/04
Ainsliadimer C
interleukin-1 beta
macrophages
NLRP3 inflammasome
Sirtuin 1
adipose tissue inflammation
obesity
metabolic disorders
EX-527
dexamethasone
SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade
期刊论文
EMBO JOURNAL, 2021, 页码: 16
作者:
Wang, Xu
;
Ni, Jiahui
;
You, Yan
;
Feng, Guize
;
Zhang, Sulin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/12/16
E-cadherin
IBD
intestinal barrier function
LPS release
SNX10
Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells
期刊论文
LIFE SCIENCES, 2021, 卷号: 284, 页码: 7
作者:
Wang, Yuqiu
;
Duan, Tianbi
;
Hong, Minhua
;
Zhou, Yanting
;
Huang, Hui
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
Silk fibroin
Quantitative proteomics
Melanin
Microphthalmia-associated transcription factor
Tyrosinase
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
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